Caryophyllene oxide exhibits anti-cancer effects in MG-63 human osteosarcoma cells via the inhibition of cell migration, generation of reactive oxygen species and induction of apoptosis

doi:10.3329/bjp.v11i4.27517

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	Caryophyllene oxide exhibits anti-cancer effects in MG-63 human osteosarcoma cells via the inhibition of cell migration, generation of reactive oxygen species and induction of apoptosis
	Pan, Z; Wang, SK; Cheng, XL; Tian, XW; Wang, J; Wang, SK (reprint author), Lanzhou Univ, Hosp 2, Orthopaed Key Lab Gansu Prov, Lanzhou, Peoples R China.
刊名	BANGLADESH JOURNAL OF PHARMACOLOGY
	2016
卷号	11 期号:4 页码:817-823
ISSN号	1991-007X
DOI	10.3329/bjp.v11i4.27517
文献子类	Article
英文摘要	The main objective of the present study was to evaluate the antitumor and apoptotic effects of caryophyllene oxide in MG-63 human osteosarcoma cells. Cell viability of these cells was evaluated by MTT assay while as in vitro wound healing assay was used to study the effect of caryophyllene oxide on cell migration. Fluorescence microscopy and transmission electron microscopy were used to study the changes in cell morphology once the cells undergo apoptosis. Caryophyllene oxide significantly led to cytotoxicity in MG-63 cells showing dose-dependent as well as time-dependent effects. Caryophyllene oxide led to an inhibition of wound closure significantly. At caryophyllene oxide doses of 20, 80 and 120 mu M, the percentage of cell migration was shown to be 94.2, 67.1 and 14.8% respectively. With an increase in the caryophyllene oxide dose, the extent of apoptosis also increased characterized by cellular shrinkage, membrane blebbing, chromatin condensation and apoptotic body formation.
学科主题	Pharmacology & Pharmacy
出版地	SHAHBAH
资助项目	国家自然科学基金项目 ; 甘肃省自然科学基金计划
项目编号	Gansu Provincial Natural Science Foundation of China [2013GS10047]
语种	英语
WOS记录号	WOS:000390319200008
资助机构	NSFC ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188668]
专题	第二临床医学院_期刊论文
通讯作者	Wang, SK (reprint author), Lanzhou Univ, Hosp 2, Orthopaed Key Lab Gansu Prov, Lanzhou, Peoples R China.
推荐引用方式 GB/T 7714	Pan, Z,Wang, SK,Cheng, XL,et al. Caryophyllene oxide exhibits anti-cancer effects in MG-63 human osteosarcoma cells via the inhibition of cell migration, generation of reactive oxygen species and induction of apoptosis[J]. BANGLADESH JOURNAL OF PHARMACOLOGY,2016,11(4):817-823.
APA	Pan, Z,Wang, SK,Cheng, XL,Tian, XW,Wang, J,&Wang, SK .(2016).Caryophyllene oxide exhibits anti-cancer effects in MG-63 human osteosarcoma cells via the inhibition of cell migration, generation of reactive oxygen species and induction of apoptosis.BANGLADESH JOURNAL OF PHARMACOLOGY,11(4),817-823.
MLA	Pan, Z,et al."Caryophyllene oxide exhibits anti-cancer effects in MG-63 human osteosarcoma cells via the inhibition of cell migration, generation of reactive oxygen species and induction of apoptosis".BANGLADESH JOURNAL OF PHARMACOLOGY 11.4(2016):817-823.