CB1 receptor antagonism prevents long-term hyperexcitability after head injury by regulation of dynorphin-KOR system and mGluR5 in rat hippocampus

doi:10.1016/j.brainres.2016.05.055

CORC > 兰州大学 > 兰州大学 > 第二临床医学院 > 期刊论文

	CB1 receptor antagonism prevents long-term hyperexcitability after head injury by regulation of dynorphin-KOR system and mGluR5 in rat hippocampus
	Wang, X; Wang, Y; Zhang, C; Liu, C; Zhao, BT; Wei, NL; Zhang, JG; Zhang, K; Zhang, K (reprint author), Beijing Tiantan Hosp, Dept Neurosurg, Tiantan Xili 6, Beijing 100050, Peoples R China.
刊名	BRAIN RESEARCH
	2016-09-01
卷号	1646 页码:174-181
关键词	Post-traumatic epilepsy Prevention Endocannabinoid Dynorphin Metabotropic glutamate receptor
ISSN号	0006-8993
DOI	10.1016/j.brainres.2016.05.055
文献子类	Article
英文摘要	Both endocannabinoids and dynorphin are feedback messengers in nervous system that act at the presynaptic nerve terminal to inhibit transmitter release. Many studies showed the cannabinoid-opioid cross-modulation in antinociception, hypothermia, sedation and reward. The aim of this study was to assess the influence of early application of cannabinoid type 1 (CB1) receptor antagonism SR141716A after brain injury on dynorphin-x opioid receptor (KOR) system and the expression of metabotropic glutamate receptors (mGluRs) in a rat model of fluid percussion injury (FPI). Firstly, seizure latency induced by pentylenetetrazole was significantly prolonged 6 weeks after brain injury in group of SR141716A treatment. Then, PCR and western blot showed that SR141716A inhibited the long-term up regulation of CB1 receptors in hippocampus. However, SR141716A resulted in long-term potentiation of dynorphin release and did not influence the up-regulation of KOR in hippocampus after brain injury. Furthermore, SR141716A reverse the overexpression of mGluR5 in the late stage of brain injury. We propose that during the induction of epileptogenesis after brain injury, early application of CB1 receptor antagonism could prevent long-term hyperexcitability by up-regulation of dynorphin-KOR system and prevention of mGluR5 induced epileptogenesis in hippocampus. (C) 2016 Elsevier B.V. All rights reserved.
学科主题	Neurosciences & Neurology
出版地	AMSTERDAM
资助项目	国家自然科学基金项目
项目编号	National Natural Science Foundation of China [81171218] ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding [XM201304, ZY201305]
语种	英语
WOS记录号	WOS:000381844700019
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179464]
专题	第二临床医学院_期刊论文
通讯作者	Zhang, K (reprint author), Beijing Tiantan Hosp, Dept Neurosurg, Tiantan Xili 6, Beijing 100050, Peoples R China.
推荐引用方式 GB/T 7714	Wang, X,Wang, Y,Zhang, C,et al. CB1 receptor antagonism prevents long-term hyperexcitability after head injury by regulation of dynorphin-KOR system and mGluR5 in rat hippocampus[J]. BRAIN RESEARCH,2016,1646:174-181.
APA	Wang, X.,Wang, Y.,Zhang, C.,Liu, C.,Zhao, BT.,...&Zhang, K .(2016).CB1 receptor antagonism prevents long-term hyperexcitability after head injury by regulation of dynorphin-KOR system and mGluR5 in rat hippocampus.BRAIN RESEARCH,1646,174-181.
MLA	Wang, X,et al."CB1 receptor antagonism prevents long-term hyperexcitability after head injury by regulation of dynorphin-KOR system and mGluR5 in rat hippocampus".BRAIN RESEARCH 1646(2016):174-181.