OS 02-04 ASTRAGALOSIDE IV IMPROVES LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN HYPERTENSIVE MICE BY INCREASING THE PHOSPHORYLATION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE.

doi:10.1097/01.hjh.0000499979.10047.58

CORC > 兰州大学 > 兰州大学 > 第二临床医学院 > 期刊论文

	OS 02-04 ASTRAGALOSIDE IV IMPROVES LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN HYPERTENSIVE MICE BY INCREASING THE PHOSPHORYLATION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE.
	Wang, Qiongying; Euy-Myoung, Jeong; Liu, Hong; Gu, Lianzhi; Dudley, Samuel C Jr; Yu, Jing
刊名	Journal of hypertension
	2016-09
卷号	34 Suppl 1 页码:e48-e49
ISSN号	1473-5598
DOI	10.1097/01.hjh.0000499979.10047.58
文献子类	Article
英文摘要	OBJECTIVE: The saponin Astragaloside IV (ASI) reportedly enhances endothelial NOS (eNOS) activity by increasing the scavenging of reactive oxygen species (ROS) and NO production. We hypothesized that oxidative stress may decrease eNOS phosphorylation and result in diastolic dysfunction in DOCA-salt mice, which could be reversed by ASI treatment.DESIGN AND METHOD: We used the deoxycorticosterone acetate (DOCA)-salt mouse model. The mice were divided into four groups; SHAM and DOCA control mice received sterile water, SHAM+ASI and DOCA+ASI received ASI treatment via an intraperitoneal injection of 0.02 mg/kg/day for 7 days. Diastolic function was assessed by echocardiography and IonOptix. The levels of eNOS monomers, dimers and phosphorylation were determined with a Western blot analysis. High performance liquid chromatography was used to measure the cardiac superoxide anions and biopterins.RESULTS: DOCA mice exhibited diastolic dysfunction that was reversed after ASI treatment (E'/A': SHAM vs. DOCA 1.27?±?0.13 vs. 0.62?±?0.07, p?
语种	英语
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179457]
专题	第二临床医学院_期刊论文
推荐引用方式 GB/T 7714	Wang, Qiongying,Euy-Myoung, Jeong,Liu, Hong,et al. OS 02-04 ASTRAGALOSIDE IV IMPROVES LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN HYPERTENSIVE MICE BY INCREASING THE PHOSPHORYLATION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE.[J]. Journal of hypertension,2016,34 Suppl 1:e48-e49.
APA	Wang, Qiongying,Euy-Myoung, Jeong,Liu, Hong,Gu, Lianzhi,Dudley, Samuel C Jr,&Yu, Jing.(2016).OS 02-04 ASTRAGALOSIDE IV IMPROVES LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN HYPERTENSIVE MICE BY INCREASING THE PHOSPHORYLATION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE..Journal of hypertension,34 Suppl 1,e48-e49.
MLA	Wang, Qiongying,et al."OS 02-04 ASTRAGALOSIDE IV IMPROVES LEFT VENTRICULAR DIASTOLIC DYSFUNCTION IN HYPERTENSIVE MICE BY INCREASING THE PHOSPHORYLATION OF ENDOTHELIAL NITRIC OXIDE SYNTHASE.".Journal of hypertension 34 Suppl 1(2016):e48-e49.