Genetic association study of ABCB1 gene polymorphisms with hypertension in Han Chinese population.

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	Genetic association study of ABCB1 gene polymorphisms with hypertension in Han Chinese population.
	Zhang, X-W; Yang, J-L; Liang, W; Hu, X-B; Bai, F; Yu, H; Yu, J; Yu, J (reprint author), Lanzhou Univ, Hosp 2, Hosp Cardiol, Sect Hypertens, Lanzhou, Gansu, Peoples R China.
刊名	European review for medical and pharmacological sciences
	2016-09
卷号	20 期号:17 页码:3661-3671
关键词	Hypertension ABCB1 SNP Association Han Chinese population
ISSN号	2284-0729
文献子类	Article
英文摘要	OBJECTIVE: Hypertension is a common disorder related to cardiovascular diseases and stroke. Identification of genetic variations related to hypertension may advance our knowledge of the molecular mechanism underlying blood pressure regulation. Here, we aimed to investigate the associations between ABCB1 gene polymorphisms and hypertension-related traits in 1154 Han Chinese subjects. PATIENTS AND METHODS: A total of 13 SNPs in ABCB1 were genotyped. RESULTS: Three SNPs were significantly associated with systolic blood pressure (SBP), including rs17327624 (p = 6.167 x 10(-4), beta = 5.650), rs3789243 (p = 4.331 x 10(-3), beta = 2.800), and rs4148734 (p = 3.514 x 10(-3), beta = 3.692). Rs17327624 (p = 2.818 x 10(-4), beta = 2.753) and rs3789243 (p = 6.345 x 10(-3), beta = 1.497) were significantly associated with diastolic blood pressure (DBP) and rs17327624 was significantly associated with hypertension (p = 1.746 x 10(-4), OR = 1.605). These three SNPs (rs17327624, rs3789243 and rs4148734) were also associated with hypertension in female subjects but no significant signal was detected in males. CONCLUSIONS: Our results suggest that ABCB1 polymorphisms may contribute to the blood pressure variation in Han Chinese population and the effect may be specific in females. Further studies performed in other populations are needed to confirm our findings and elucidate the underlying molecular mechanism.
学科主题	Pharmacology & Pharmacy
出版地	ROME
资助项目	甘肃省自然科学基金计划 ; 兰州市科技局资助项目
项目编号	west light foundation of the Chinese academy of sciences ; natural science foundation of Gansu province [1501RJZA003] ; science projects of Lanzhou city [2015-2-51]
语种	英语
WOS记录号	WOS:000386563600022
资助机构	GSSTD ; LZSTB
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179456]
专题	第二临床医学院_期刊论文
通讯作者	Yu, J (reprint author), Lanzhou Univ, Hosp 2, Hosp Cardiol, Sect Hypertens, Lanzhou, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, X-W,Yang, J-L,Liang, W,et al. Genetic association study of ABCB1 gene polymorphisms with hypertension in Han Chinese population.[J]. European review for medical and pharmacological sciences,2016,20(17):3661-3671.
APA	Zhang, X-W.,Yang, J-L.,Liang, W.,Hu, X-B.,Bai, F.,...&Yu, J .(2016).Genetic association study of ABCB1 gene polymorphisms with hypertension in Han Chinese population..European review for medical and pharmacological sciences,20(17),3661-3671.
MLA	Zhang, X-W,et al."Genetic association study of ABCB1 gene polymorphisms with hypertension in Han Chinese population.".European review for medical and pharmacological sciences 20.17(2016):3661-3671.