Acute Pancreatitis Classifications: Basis and Key Goals

doi:10.1097/MD.0000000000002182

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	Acute Pancreatitis Classifications: Basis and Key Goals
	Xu, XD; Wang, ZY; Zhang, LY; Ni, R; Wei, FX; Han, W; Zhang, HH; Zhang, YW; Wei, ZG; Guo, XH
刊名	MEDICINE
	2015-12
卷号	94 期号:48
ISSN号	0025-7974
DOI	10.1097/MD.0000000000002182
文献子类	Article
英文摘要	To explore the efficacy of the revised Atlanta classification (RACAP) and the determinant-based classification of acute pancreatitis severity (DBCAPS) on the basis of clinical data and feedback from patients with acute pancreatitis (AP).The authors retrospectively investigated a total of 573 patients with AP admitted to our hospital between December 2011 and December 2014. The definitions of severity and local complications in AP using RACAP and DBCAPS are presented and common points and mutual differences between the 2 groups are analyzed and discussed.Classification according to RACAP and DBCAPS found 86 (15%) and 178 (31.1%) mild cases (P<0.01), 269 (46.9%) and 176 (30.7%) moderate cases (P<0.01), and 218 (38.0%) and 219 (38.2%) severe cases (P=0.95), respectively. A major contribution of DBCAPS is the introduction of a new type of severe AP, critical AP, identified in 4 patients (0.7%). Complications were observed in 313 RACAP-defined cases and 153 DBCAPS-defined cases (P<0.01). Among the 313 RACAP-defined cases, acute peripancreatic fluid collection (236 patients, 75.40%), pancreatic pseudocysts (20 patients, 6.4%), acute necrotic collection (42 patients, 13.4%), and walled-off necrosis (15 patients, 4.8%) were observed. Among the 153 DBCAPS-defined cases, sterile peripancreatic necrosis (105 patients, 68.6%), sterile pancreatic necrosis (44 patients, 28.8%), infected peripancreatic necrosis (2 patients, 1.3%), and infected pancreatic necrosis (2/153 patients, 1.3%) were observed.Both classifications adopted organ failure and complications as determinants of severity. Revised Atlanta classification refined local complications and DBCAPS modified severity to include critical AP. In accordance with the demands of precision medicine, a combination of the 2 could be important for further clinical practice and scientific research.
学科主题	General & Internal Medicine
出版地	PHILADELPHIA
资助项目	国家自然科学基金项目 ; 甘肃省自然科学基金计划
项目编号	Gansu Province Natural Science Foundation [145RJZA177]
语种	英语
WOS记录号	WOS:000369540400020
资助机构	NSFC ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179410]
专题	第二临床医学院_期刊论文
通讯作者	Zhang, YC (reprint author), Lanzhou Univ, Hosp 2, Dept Gen Surg, Cuiyingmen 82, Lanzhou 730030, Peoples R China.
推荐引用方式 GB/T 7714	Xu, XD,Wang, ZY,Zhang, LY,et al. Acute Pancreatitis Classifications: Basis and Key Goals[J]. MEDICINE,2015,94(48).
APA	Xu, XD.,Wang, ZY.,Zhang, LY.,Ni, R.,Wei, FX.,...&Zhang, YC .(2015).Acute Pancreatitis Classifications: Basis and Key Goals.MEDICINE,94(48).
MLA	Xu, XD,et al."Acute Pancreatitis Classifications: Basis and Key Goals".MEDICINE 94.48(2015).