The Efficacy and Safety of Granulocyte Colony-Stimulating Factor for Patients with Stroke

doi:10.1016/j.jstrokecerebrovasdis.2014.11.033

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	The Efficacy and Safety of Granulocyte Colony-Stimulating Factor for Patients with Stroke
	Fan, ZZ; Cai, HB; Ge, ZM; Wang, LQ; Zhang, XD; Li, L; Zhai, XB; Ge, ZM (reprint author), Lanzhou Univ, Dept Neurol, Hosp 2, 82 Cuiyingmen, Lanzhou 730030, Gansu, Peoples R China.
刊名	JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
	2015-08
卷号	24 期号:8 页码:1701-1708
关键词	Stroke granulocyte colony-stimulating factor (G-CSF) hematopoietic stem cell meta-analysis
ISSN号	1052-3057
DOI	10.1016/j.jstrokecerebrovasdis.2014.11.033
文献子类	Article
英文摘要	Background: Granulocyte colony-stimulating factor (G-CSF) has been shown to reduce lesion volume and improve functional outcome in experimental stroke models. However, whether G-CSF plays a role currently in patients with stroke remains uncertain. Our study aimed at examining the efficacy and safety of G-CSF in patients with acute ischemic stroke. Methods: A comprehensive search was conducted in 5 online databases up to April 2014, and 10 studies with 711 patients met the criteria. Results: The results showed that G-CSF was beneficial in improving the National Institutes of Health Stroke Scale (standardized mean difference [SMD], .43; 95% confidence interval [CI], .03-.82; P = .04) and modified Rankin Scale (mRS) scores (SMD, .72; 95% CI, .51-.93; P = .01), and elevating CD34(+) count (P < .001). No treatment effects were found in Barthel Index scores (SMD, -.13; 95% CI, -.61 to .35; P = .59), serious adverse events (relative ratio [RR], 1.12; 95% CI, .91-1.38; P = .28), or the death of serious adverse events (RR, 1.25; 95% CI, .82-1.91; P = .30) between groups at day 90. Adverse effect on vascular complications was not detected to be increased although G-CSF produced a marked elevation in the total leukocyte count (SMD, 3.52; 95% CI, 2.54-4.49; P < .001). Conclusions: In conclusion, G-CSF is effective at mobilizing bone marrow-derived CD34(+) stem cells to the peripheral blood. It also seems to improve the National Institutes of Health Stroke Scale and mRS scores. The administration of G-CSF appears to be safe and well tolerated. Further studies need to be done on a large sample to verify or fully characterize the results. (C) 2015 by National Stroke Association
学科主题	Neurosciences & Neurology ; Cardiovascular System & Cardiology
出版地	AMSTERDAM
资助项目	甘肃省自然科学基金计划
项目编号	Natural Science Foundation of Gansu Province [1107RJZA082]
语种	英语
WOS记录号	WOS:000359300000013
资助机构	GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179383]
专题	第二临床医学院_期刊论文
通讯作者	Ge, ZM (reprint author), Lanzhou Univ, Dept Neurol, Hosp 2, 82 Cuiyingmen, Lanzhou 730030, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Fan, ZZ,Cai, HB,Ge, ZM,et al. The Efficacy and Safety of Granulocyte Colony-Stimulating Factor for Patients with Stroke[J]. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES,2015,24(8):1701-1708.
APA	Fan, ZZ.,Cai, HB.,Ge, ZM.,Wang, LQ.,Zhang, XD.,...&Ge, ZM .(2015).The Efficacy and Safety of Granulocyte Colony-Stimulating Factor for Patients with Stroke.JOURNAL OF STROKE & CEREBROVASCULAR DISEASES,24(8),1701-1708.
MLA	Fan, ZZ,et al."The Efficacy and Safety of Granulocyte Colony-Stimulating Factor for Patients with Stroke".JOURNAL OF STROKE & CEREBROVASCULAR DISEASES 24.8(2015):1701-1708.