Sparse whole-genome sequencing identifies two loci for major depressive disorder

doi:10.1038/nature14659

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	Sparse whole-genome sequencing identifies two loci for major depressive disorder
	Cai, N; Bigdeli, TB; Kretzschmar, W; Li, YH; Liang, JQ; Song, L; Hu, JC; Li, QB; Jin, W; Hu, ZF
刊名	NATURE
	2015-07-30
卷号	523 期号:7562 页码:588
ISSN号	0028-0836
DOI	10.1038/nature14659
文献子类	Article
英文摘要	Major depressive disorder (MDD), one of the most frequently encountered forms ofmental illness and a leading cause of disability worldwide(1), poses a major challenge to genetic analysis. To date, no robustly replicated genetic loci have been identified(2), despite analysis of more than 9,000 cases(3). Here, using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, we identified, and subsequently replicated in an independent sample, two loci contributing to risk of MDD on chromosome 10: one near the SIRT1 gene (P = 2.53 x 10(-10)), the other in an intron of the LHPP gene (P = 6.45 x10(-12)). Analysis of 4,509 cases with a severe subtype of MDD, melancholia, yielded an increased genetic signal at the SIRT1 locus. We attribute our success to the recruitment of relatively homogeneous cases with severe illness.
学科主题	Science & Technology - Other Topics
出版地	LONDON
资助项目	国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划（973计划） ; 美国国立卫生研究院项目 ; 英国惠康基金会项目
项目编号	Wellcome Trust [WT090532/Z/09/Z, WT083573/Z/07/Z, WT089269/Z/09/Z, WT097307] ; NIH [MH-100549] ; Brain and Behavior Research Foundation ; Agency of Science, Technology and Research (A*STAR) Graduate Academy ; ERC [617306] ; 973 Program [2013CB531301] ; NSFC [31430048, 31222031]
语种	英语
WOS记录号	WOS:000358655200044
资助机构	NSFC ; MOST ; NIH ; Wellcome Trust
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179379]
专题	第二临床医学院_期刊论文
通讯作者	Cai, N (reprint author), Univ Oxford, Wellcome Trust Ctr Human Genet, Roosevelt Dr, Oxford OX3 7BN, England.
推荐引用方式 GB/T 7714	Cai, N,Bigdeli, TB,Kretzschmar, W,et al. Sparse whole-genome sequencing identifies two loci for major depressive disorder[J]. NATURE,2015,523(7562):588.
APA	Cai, N.,Bigdeli, TB.,Kretzschmar, W.,Li, YH.,Liang, JQ.,...&Cai, N .(2015).Sparse whole-genome sequencing identifies two loci for major depressive disorder.NATURE,523(7562),588.
MLA	Cai, N,et al."Sparse whole-genome sequencing identifies two loci for major depressive disorder".NATURE 523.7562(2015):588.