Interactional role of microRNAs and bHLH-PAS proteins in cancer (Review)

doi:10.3892/ijo.2015.3007

CORC > 兰州大学 > 兰州大学 > 第二临床医学院 > 期刊论文

	Interactional role of microRNAs and bHLH-PAS proteins in cancer (Review)
	Li, YM; Wei, YC; Guo, JW; Cheng, YS; He, WT; Li, YM (reprint author), Lanzhou Univ, Hosp 2, Key Lab Digest Syst Tumors Gansu Prov, 82 Cuiyingmen, Lanzhou 730000, Gansu, Peoples R China.
刊名	INTERNATIONAL JOURNAL OF ONCOLOGY
	2015-07
卷号	47 期号:1 页码:25-34
关键词	microRNA bHLH-PAS protein hypoxia-inducible factor aryl hydrocarbon receptor cancer
ISSN号	1019-6439
DOI	10.3892/ijo.2015.3007
文献子类	Review
英文摘要	MicroRNAs (miRNAs) are recognized as an emerging class of master regulators that regulate human gene expression at the post-transcriptional level and are involved in many normal and pathological cellular processes. Mammalian basic HLH (helix-loop-helix)-PER-ARNT-SIM (bHLH-PAS) proteins are heterodimeric transcriptional regulators that sense and respond to environmental signals (such as chemical pollutants) or to physiological signals (for instance hypoxia). In the normal state, bHLH-PAS proteins are responsible for multiple critical aspects of physiology to ensure the cell accurate homeostasis, but dysregulation of these proteins has been shown to contribute to carcinogenic events such as tumor initiation, promotion, and progression. Increasing epidemiological and experimental studies have shown that bHLH-PAS proteins regulate a panel of miRNAs, whereas some miRNAs also target bHLH-PAS proteins. The interaction between miRNAs and certain bHLH-PAS proteins [hypoxia-inducible factor (HIF) and aryl hydrocarbon receptor (AHR)1 is relevant to many vital events associated with tumorigenesis. This review will summarize recent findings on the interesting and complicated underlying mechanisms that miRNAs interact with HIFs or AHR in tumors, hopefully to benefit the discovery of novel drug-interfering targets for cancer therapy.
学科主题	Oncology
出版地	ATHENS
资助项目	国家自然科学基金项目 ; 中央高校基本科研业务费专项资金
项目编号	National Natural Science Foundation of China [31270532] ; Central College Basic Scientific Research Foundation of Lanzhou University [lzujbky-2013-m04]
语种	英语
WOS记录号	WOS:000356468100003
资助机构	NSFC ; LZU
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179373]
专题	第二临床医学院_期刊论文
通讯作者	Li, YM (reprint author), Lanzhou Univ, Hosp 2, Key Lab Digest Syst Tumors Gansu Prov, 82 Cuiyingmen, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Li, YM,Wei, YC,Guo, JW,et al. Interactional role of microRNAs and bHLH-PAS proteins in cancer (Review)[J]. INTERNATIONAL JOURNAL OF ONCOLOGY,2015,47(1):25-34.
APA	Li, YM,Wei, YC,Guo, JW,Cheng, YS,He, WT,&Li, YM .(2015).Interactional role of microRNAs and bHLH-PAS proteins in cancer (Review).INTERNATIONAL JOURNAL OF ONCOLOGY,47(1),25-34.
MLA	Li, YM,et al."Interactional role of microRNAs and bHLH-PAS proteins in cancer (Review)".INTERNATIONAL JOURNAL OF ONCOLOGY 47.1(2015):25-34.