Effect of Acute and Chronic Exposure to High Altitude on the Aerobic and Anaerobic Metabolism in Rats

doi:10.1155/2015/159549

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	Effect of Acute and Chronic Exposure to High Altitude on the Aerobic and Anaerobic Metabolism in Rats
	Ni, Q; Wan, FQ; Jing, YH; Dong, XY; Zhang, YC; Zhang, YC (reprint author), Lanzhou Univ, Hosp 2, Hepatic Biliary Pancreat Inst, Dept Gen Surg, Lanzhou 730000, Peoples R China.
刊名	ANALYTICAL CELLULAR PATHOLOGY
	2015
ISSN号	2210-7177
DOI	10.1155/2015/159549
文献子类	Article
英文摘要	In this study, we aimed to investigate the effect of acute and chronic exposure to HA on the aerobic and anaerobic metabolism in liver by determining the hepatic levels of ICDH and ATP. Lactate levels in liver and blood were also examined. Rats were exposed to an altitude of 4,300 m for 30 days, and those without HA exposure were used as controls. We observed an increased expression of liver ICDH following acute exposure (days 1, 3, and 7), whereas the liver ATP concentration was reduced on day 1. No changes in the hepatic expression of ICDH and ATP were found in rats chronically exposed to HA. Lactate concentrations of liver and blood did not show any significant changes following HA exposure. Thus, aerobic metabolism may be the major metabolic pathway in response to HA hypoxia in order to acclimatize themselves to the stressful environments.
学科主题	Oncology ; Cell Biology ; Pathology
出版地	NEW YORK
语种	英语
WOS记录号	WOS:000365228600001
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179313]
专题	第二临床医学院_期刊论文
通讯作者	Zhang, YC (reprint author), Lanzhou Univ, Hosp 2, Hepatic Biliary Pancreat Inst, Dept Gen Surg, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Ni, Q,Wan, FQ,Jing, YH,et al. Effect of Acute and Chronic Exposure to High Altitude on the Aerobic and Anaerobic Metabolism in Rats[J]. ANALYTICAL CELLULAR PATHOLOGY,2015.
APA	Ni, Q,Wan, FQ,Jing, YH,Dong, XY,Zhang, YC,&Zhang, YC .(2015).Effect of Acute and Chronic Exposure to High Altitude on the Aerobic and Anaerobic Metabolism in Rats.ANALYTICAL CELLULAR PATHOLOGY.
MLA	Ni, Q,et al."Effect of Acute and Chronic Exposure to High Altitude on the Aerobic and Anaerobic Metabolism in Rats".ANALYTICAL CELLULAR PATHOLOGY (2015).