Quercetin inhibits human sperm functions by reducing sperm [Ca2+](i) and tyrosine phosphorylation

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	Quercetin inhibits human sperm functions by reducing sperm [Ca2+](i) and tyrosine phosphorylation
	Liang, XL; Xia, ZL; Yan, JX; Wang, YQ; Xue, SL; Zhang, XH; Liang, XL (reprint author), Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China.
刊名	PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
	2016-11
卷号	29 期号:6 页码:2391-2396
关键词	Quercetin sperm [Ca2+](i) tyrosine phosphorylation
ISSN号	1011-601X
文献子类	Article
英文摘要	Quercetin is widely known as potent natural antioxidant and scavenger of reactive oxygen sp(xies (ROS) and nitric oxide both in vitro and in vivo. Quercetin has a wide range of biological functions and health-promoting effects. There are more and more interests in the addition of this flavonol to various traditional food products. However, the in vitro toxicity of quercetin to mature human sperm remains unknown. In this study, we investigated the in vitro effects of quercetin on human sperm functions. The results showed that the total sperm motility were significantly inhibited compared to the controls following exposure to 100, 200 and 400 mu M quercetin for 6 and 12h; quercetin did not affect human sperm viability. The acrosome reaction and capacitation induced by progesterone were dose-dependently inhibited by quercetin. Furthermore, quercetin induced a significantly decrease of human sperm [Ca2+](i) after 2 min above 50 mu M, and dose-dependently decreased the protein-tyrosine phosphorylation of human sperm. Our results indicated that quercetin may decrease sperm [Ca2+](i), suppresse tyrosine phosphorylation, and subsequently inhibit sperm functions.
学科主题	Pharmacology & Pharmacy
出版地	KARACHI
资助项目	国家自然科学基金项目 ; 甘肃省自然科学基金计划
项目编号	National Natural Science Foundation of China [81601351] ; Science Foundation of the Gansu Province China [1606RJZA133]
语种	英语
WOS记录号	WOS:000394407000020
资助机构	NSFC ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188660]
专题	第一临床医学院_期刊论文
通讯作者	Liang, XL (reprint author), Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China.
推荐引用方式 GB/T 7714	Liang, XL,Xia, ZL,Yan, JX,et al. Quercetin inhibits human sperm functions by reducing sperm [Ca2+](i) and tyrosine phosphorylation[J]. PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES,2016,29(6):2391-2396.
APA	Liang, XL.,Xia, ZL.,Yan, JX.,Wang, YQ.,Xue, SL.,...&Liang, XL .(2016).Quercetin inhibits human sperm functions by reducing sperm [Ca2+](i) and tyrosine phosphorylation.PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES,29(6),2391-2396.
MLA	Liang, XL,et al."Quercetin inhibits human sperm functions by reducing sperm [Ca2+](i) and tyrosine phosphorylation".PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES 29.6(2016):2391-2396.