Monoammonium glycyrrhizinate protects rifampicin- and isoniazid-induced hepatotoxicity via regulating the expression of transporter Mrp2, Ntcp, and Oatp1a4 in liver

doi:10.3109/13880209.2015.1070878

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	Monoammonium glycyrrhizinate protects rifampicin- and isoniazid-induced hepatotoxicity via regulating the expression of transporter Mrp2, Ntcp, and Oatp1a4 in liver
	Zhou, LT; Song, YQ; Zhao, J; Qin, HY; Zhang, GQ; Zhou, Y; Wu, XA; Wu, XA (reprint author), Lanzhou Univ, Hosp 1, Dept Pharm, Lanzhou 730000, Peoples R China.
刊名	PHARMACEUTICAL BIOLOGY
	2016-06-02
卷号	54 期号:6 页码:931-937
关键词	hepatoprotective Anti-tuberculosis agent liver injury glycyrrhizin acid
ISSN号	1388-0209
DOI	10.3109/13880209.2015.1070878
文献子类	Article
英文摘要	Context: Drug-induced liver injury (DILI) is associated with altering expression of hepatobiliary membrane transporters. Monoammonium glycyrrhizin (MAG) is commonly used for hepatic protection and may have a correlation with the inhibition effect of multidrug resistance-associated protein 2 (Mrp2). Objective: This study evaluates the dynamic protective effect of MAG on rifampicin (RIF)- and isoniazid (INH)-induced hepatotoxicity in rats. Materials and methods: Male Wistar rats were randomly divided into four groups of 15 rats. Liver injury was induced by co-treatment with RIF (60 mg/kg) and INH (60 mg/kg) by gavage administration; MAG was orally pretreated at the doses of 45 or 90 mg/kg 3 h before RIF and INH. Rats in each group were sacrificed at 7, 14, and 21 d time points after drug administration. Results: Liver function, histopathological analysis, and oxidative stress factors were significantly altered in each group. The expression of Mrp2 was significantly increased 230, 760, and 990% at 7, 14, and 21 time points, respectively, in RIF- and INH-treated rats. Compared with the RIF and INH groups, Mrp2 was reduced and Ntcp was significantly elevated by 180, 140, and 160% in the MAG high-dose group at the three time points, respectively. The immunoreaction intensity of Oatp1a4 was increased 170, 190, and 370% in the MAG low-dose group and 160, 290, and 420% in the MAG high-dose group at the three time points, respectively, compared with the RIF and INH groups. Discussion and conclusion: These results indicated that MAG has a protective effects against RIF- and INH-induced hepatotoxicity. The underlying mechanism may have correlation with its effect on regulating the expression of hepatobiliary membrane transporters.
学科主题	Plant Sciences ; Medical Laboratory Technology ; Pharmacology & Pharmacy
出版地	ABINGDON
资助项目	国家自然科学基金项目
项目编号	National Natural Science Foundation of China [81373494, 81041086]
语种	英语
WOS记录号	WOS:000373977600001
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/178656]
专题	第一临床医学院_期刊论文
通讯作者	Wu, XA (reprint author), Lanzhou Univ, Hosp 1, Dept Pharm, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Zhou, LT,Song, YQ,Zhao, J,et al. Monoammonium glycyrrhizinate protects rifampicin- and isoniazid-induced hepatotoxicity via regulating the expression of transporter Mrp2, Ntcp, and Oatp1a4 in liver[J]. PHARMACEUTICAL BIOLOGY,2016,54(6):931-937.
APA	Zhou, LT.,Song, YQ.,Zhao, J.,Qin, HY.,Zhang, GQ.,...&Wu, XA .(2016).Monoammonium glycyrrhizinate protects rifampicin- and isoniazid-induced hepatotoxicity via regulating the expression of transporter Mrp2, Ntcp, and Oatp1a4 in liver.PHARMACEUTICAL BIOLOGY,54(6),931-937.
MLA	Zhou, LT,et al."Monoammonium glycyrrhizinate protects rifampicin- and isoniazid-induced hepatotoxicity via regulating the expression of transporter Mrp2, Ntcp, and Oatp1a4 in liver".PHARMACEUTICAL BIOLOGY 54.6(2016):931-937.