The immunosuppression role of alpha-fetoprotein in human hepatocellular carcinoma.

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	The immunosuppression role of alpha-fetoprotein in human hepatocellular carcinoma.
	Meng, Wenbo; Bai, Bing; Bai, Zhongtian; Li, Yan; Yue, Ping; Li, Xun; Qiao, Liang; Li, X (reprint author), Lanzhou Univ, Hosp 1, Dept Gen Surg 2, Lanzhou 730000, Gansu, Peoples R China.; Li, X (reprint author), Lanzhou Univ, Hepatopancreatobiliary Surg Inst Gansu Prov, Clin Med Coll, Ctr Canc, Lanzhou 730000, Gansu, Peoples R China.; Li, X (reprint author), Biol Therapy & Regenerat Med Transformat Ctr Gans, Lanzhou 730000, Gansu, Peoples R China.
刊名	Discovery medicine
	2016-06
卷号	21 期号:118 页码:489-494
ISSN号	1944-7930
文献子类	Article
英文摘要	Human hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death. Alpha-fetoprotein (AFP) is perhaps the best-defined tumor marker for HCC, and as such, it is widely used in clinical settings as an adjuvant diagnostic and prognostic tool. Up to 70% of HCC cases exhibit elevated serum level of AFP, but its pathophysiological functions in HCC are poorly defined. It is now known that AFP is not just a fetal form of carrier protein and a tumor marker, it is also critically involved in the regulation of several important cellular functions, such as cell growth, differentiation, apoptosis, angiogenesis, and immune regulation. In this mini-review, we summarize the recent development of AFP in hepatocellular carcinoma.
学科主题	Research & Experimental Medicine
出版地	TIMONIUM
资助项目	国家自然科学基金项目 ; 中央高校基本科研业务费专项资金 ; 甘肃省自然科学基金计划 ; 甘肃省卫生厅资助项目
项目编号	Special Fund of 'The Basic Scientific Research in Colleges and Universities' [lzujbky-2013-m04] ; General Projects of National Natural Science Foundation of China [31270543] ; Natural Science Foundation of Gansu Province [145RJZA113] ; Health Industry Scientific Research Plan Management Project of Gansu Province [GWGL2010-23]
语种	英语
WOS记录号	WOS:000384196800006
资助机构	NSFC ; LZU ; GSSTD ; GSPHD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/178654]
专题	第一临床医学院_期刊论文
通讯作者	Li, X (reprint author), Lanzhou Univ, Hosp 1, Dept Gen Surg 2, Lanzhou 730000, Gansu, Peoples R China.; Li, X (reprint author), Lanzhou Univ, Hepatopancreatobiliary Surg Inst Gansu Prov, Clin Med Coll, Ctr Canc, Lanzhou 730000, Gansu, Peoples R China.; Li, X (reprint author), Biol Therapy & Regenerat Med Transformat Ctr Gans, Lanzhou 730000, Gansu, Peoples R China.; Qiao, L (reprint author), Univ Sydney, Westmead Hosp, Dept Med, Storr Liver Ctr,Westmead Inst Med Res, Westmead, NSW 2145, Australia.
推荐引用方式 GB/T 7714	Meng, Wenbo,Bai, Bing,Bai, Zhongtian,et al. The immunosuppression role of alpha-fetoprotein in human hepatocellular carcinoma.[J]. Discovery medicine,2016,21(118):489-494.
APA	Meng, Wenbo.,Bai, Bing.,Bai, Zhongtian.,Li, Yan.,Yue, Ping.,...&Qiao, L .(2016).The immunosuppression role of alpha-fetoprotein in human hepatocellular carcinoma..Discovery medicine,21(118),489-494.
MLA	Meng, Wenbo,et al."The immunosuppression role of alpha-fetoprotein in human hepatocellular carcinoma.".Discovery medicine 21.118(2016):489-494.