Use of semipreparative high performance liquid chromatography to obtain small quantities of the albendazole sulfoxide enantiomers

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	Use of semipreparative high performance liquid chromatography to obtain small quantities of the albendazole sulfoxide enantiomers
	Zhai, ZD; Zhang, H; Shi, YP; Chen, LR; Zhang, HL; Li, YM; Chen, LR (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China.
刊名	CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
	2005-01
卷号	33 期号:1 页码:109-112
关键词	enantiomer separation semipreparative high performance liquid chromatography albendazole sulfoxide amylose tris(3,5-dimethylphenyl carbamate) 手性拆分半制备色谱阿苯达唑亚砜直链淀粉-三(3,5-二甲基苯基氨基甲酸酯)
ISSN号	0253-3820
其他题名	用半制备高效液相色谱法制备少量的阿苯达唑亚砜单一对映体
文献子类	Article
英文摘要	A chiral stationary phase (CSP) was prepared by coating amylose tris ( 3 5-dimethyl-phenyl carbamate) (ADMPC) onto aminopropylated spherical silica gel. Broad spectrum anthelmintic agent-albendazole sulfoxide (ABZSO) was directly resolved on analytical ADMPC-CSP column by normal-phase high performance liquid chromatography (HPLC). Then, the analytical methods were scaled up to semipreparative loading to obtain small quantities of both ABZSO enantiomers. Especially, different loading amounts were investigated for their effect on various parameters of semipreparative HPLC. Using the maximum loading, about 1 g of each enantiomer were obtained in 83 h. A purity of > 99.9% and a yield of > 98. 0% was obtained for (+) ABZSO enantiomer; and a purity of > 99.0% and a yield of > 94. 0% was obtained for (-) ABZSO enantiomer.
学科主题	Chemistry
出版地	BEIJING
项目编号	国家科技部基础研究快速反应支持项目(国科基字[2001]51号) ; 中国科学院百人计划项目资助课题
语种	中文
CSCD记录号	CSCD:1907146
WOS记录号	WOS:000226805000029
资助机构	MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125944]
专题	第一临床医学院_期刊论文
通讯作者	Chen, LR (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Zhai, ZD,Zhang, H,Shi, YP,et al. Use of semipreparative high performance liquid chromatography to obtain small quantities of the albendazole sulfoxide enantiomers[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2005,33(1):109-112.
APA	Zhai, ZD.,Zhang, H.,Shi, YP.,Chen, LR.,Zhang, HL.,...&Chen, LR .(2005).Use of semipreparative high performance liquid chromatography to obtain small quantities of the albendazole sulfoxide enantiomers.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,33(1),109-112.
MLA	Zhai, ZD,et al."Use of semipreparative high performance liquid chromatography to obtain small quantities of the albendazole sulfoxide enantiomers".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 33.1(2005):109-112.