Expression of E-cadherin and beta-catenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival

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	Expression of E-cadherin and beta-catenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival
	Zhou, YN; Xu, CP; Han, B; Li, M; Qiao, L; Fang, DC; Yang, JM; Zhou, YN (reprint author), Third Mil Med Univ, SW Hosp, Dept Gastroenterol, Chongqing 400038, Peoples R China.
刊名	WORLD JOURNAL OF GASTROENTEROLOGY
	2002-12
卷号	8 期号:6 页码:987-993
ISSN号	1007-9327
文献子类	Article
英文摘要	AIM: The E-cadherin-catenin complex is important for cell-cell adhesion of epithelial cells. Impairment of one or more components of this complex is associated with poor differentiation and increased invasiveness of carcinomas. We evaluated the expression pattern of E-cadherin and beta-catenin in gastric carcinoma and dysplasia and analyzed their relationship with tumor clinicopathological features and patient survival. METHODS: Immunohistochemical staining of E-cadherin and beta-catenin was performed from paraffin specimens of 163 gastric carcinomas, 44 gastric mucosal dysplasia, and 25 intestinal metaplasia, 28 atrophic gastritis and 12 healthy controls. RESULTS: Normal membrane staining was observed in intestinal metaplasia, atrophic gastritis and control biopsy specimens for E-cadherin and beta-catenin. 36% and 16% of gastric dysplasia were stained abnormally for E-cadherin and beta-catenin respectively. Abnormal expression of E-cadherin and beta-catenin was demonstrated in 46% and 44% of gastric carcinoma respectively. Abnormal expression of E-cadherin and beta-catenin occurred more significantly in Borrmann III/IV than in Borrmann I/II type (P<0.005, respectively). A significantly higher proportion of signet-ring, mucinous and tubular adenocarcinomas were abnormally expressed for E-cadherin and beta- catenin as compared with papillary adenocarcinomas (chi(2)=8.47,P<0.005, and chi(2)=7.05, P<0.01, respectively). Morever, abnormal E-cadherin and beta-catenin staining occurred more frequently in diffuse than in intestinal type of tumor (chi(2)=18.18 and 17.79, P<0.005, respectively). There was a significant correlation between abnormal beta-catenin expression and positive lymph node metastasis. A survival advantage was noted in tumors retaining normal membranous expression of beta-catenin, independent of type, grade, or stage of the disease (P<0.0005). CONCLUSION: Abnormal expression of the E-cadherin-catenin complex occurs frequently in gatric carcinoma, closely related to its histogenesis. Abnormal expression of the E-cadherin- catenin complex in gastric dysplasia may be an early event in the tumorigenesis. The close correlation with poor survival suggests that abnormal beta-catenin may be a useful prognostic marker.
学科主题	Gastroenterology & Hepatology
出版地	BEIJING
语种	英语
WOS记录号	WOS:000179741700006
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125936]
专题	第一临床医学院_期刊论文
通讯作者	Zhou, YN (reprint author), Third Mil Med Univ, SW Hosp, Dept Gastroenterol, Chongqing 400038, Peoples R China.
推荐引用方式 GB/T 7714	Zhou, YN,Xu, CP,Han, B,et al. Expression of E-cadherin and beta-catenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2002,8(6):987-993.
APA	Zhou, YN.,Xu, CP.,Han, B.,Li, M.,Qiao, L.,...&Zhou, YN .(2002).Expression of E-cadherin and beta-catenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival.WORLD JOURNAL OF GASTROENTEROLOGY,8(6),987-993.
MLA	Zhou, YN,et al."Expression of E-cadherin and beta-catenin in gastric carcinoma and its correlation with the clinicopathological features and patient survival".WORLD JOURNAL OF GASTROENTEROLOGY 8.6(2002):987-993.