Comparison of the efficacy of octreotide, vasopressin, and omeprazole in the control of acute bleeding in patients with portal hypertensive gastropathy: A controlled study

doi:10.1046/j.1440-1746.2002.02775.x

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	Comparison of the efficacy of octreotide, vasopressin, and omeprazole in the control of acute bleeding in patients with portal hypertensive gastropathy: A controlled study
	Zhou, YN; Qiao, L; Wu, J; Hu, HW; Xu, CP; Qiao, L (reprint author), Virginia Commonwealth Univ, Med Coll Virginia, Massey Canc Ctr, Richmond, VA 23298 USA.
刊名	JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
	2002-09
卷号	17 期号:9 页码:973-979
关键词	acute bleeding octreotide omeprazole portal hypertensive gastropathy vasopressin
ISSN号	0815-9319
DOI	10.1046/j.1440-1746.2002.02775.x
文献子类	Article
英文摘要	Background: Portal hypertensive gastropathy is an important complication of liver cirrhosis and it contributes to acute gastric bleeding. Effective management of this condition remains a clinical challenge. We assessed and compared the efficacy of octreotide, vasopressin, and omeprazole in the treatment of acute bleeding in patients with portal hypertensive gastropathy. Methods: Sixty-eight patients with portal hypertensive gastropathy were randomized into Octreotide, Vasopressin, and Omeprazole groups. Bleeding was monitored by observing the contents of the nasogastric tube. Blood transfusion requirements and side-effects of drugs were recorded. Repeat endoscopies were scheduled 2 weeks after treatment. Results: Complete bleeding control after 48 h of drug infusion was achieved in all patients receiving octreotide (100%), 14/22 patients receiving vasopressin (64%), and 13/22 patients receiving Omeprazole (59%). Octreotide required much less time and significantly fewer blood transfusions to control bleeding. Patients receiving vasopressin experienced more side-effects than those receiving octreotide and omeprazole. In the 17 patients whose bleeding was not controlled within 48 h by either vasopressin or omeprazole, complete bleeding control was achieved by combined use of these two agents. Followup endoscopy showed dramatic improvement in gastric mucosal erosions, superficial ulceration and erythema. Conclusions: Octreotide appeared to be more effective in controlling acute bleeding in patients with hypertensive gastropathy, with significantly rapid action, smaller transfusion requirements, and minor side-effects. Simultaneous administration of vasopressin and omeprazole appeared to have additive effects. (C) 2002 Blackwell Publishing Asia Pty Ltd.
学科主题	Gastroenterology & Hepatology
出版地	CARLTON
语种	英语
WOS记录号	WOS:000179400700008
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125935]
专题	第一临床医学院_期刊论文
通讯作者	Qiao, L (reprint author), Virginia Commonwealth Univ, Med Coll Virginia, Massey Canc Ctr, Richmond, VA 23298 USA.
推荐引用方式 GB/T 7714	Zhou, YN,Qiao, L,Wu, J,et al. Comparison of the efficacy of octreotide, vasopressin, and omeprazole in the control of acute bleeding in patients with portal hypertensive gastropathy: A controlled study[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2002,17(9):973-979.
APA	Zhou, YN,Qiao, L,Wu, J,Hu, HW,Xu, CP,&Qiao, L .(2002).Comparison of the efficacy of octreotide, vasopressin, and omeprazole in the control of acute bleeding in patients with portal hypertensive gastropathy: A controlled study.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,17(9),973-979.
MLA	Zhou, YN,et al."Comparison of the efficacy of octreotide, vasopressin, and omeprazole in the control of acute bleeding in patients with portal hypertensive gastropathy: A controlled study".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 17.9(2002):973-979.