Deconvolution analysis for absorption and metabolism of aspirin in microcapsules

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	Deconvolution analysis for absorption and metabolism of aspirin in microcapsules
	Wu, XN; Yamashita, F; Hashida, M; Hashida, M (reprint author), Kyoto Univ, Grad Sch Pharmaceut Sci, Dept Drug Delivery Res, Sakyo Ku, Yoshida Shimoadachi Cho, Kyoto 60608501, Japan.
刊名	BIOLOGICAL & PHARMACEUTICAL BULLETIN
	1999-11
卷号	22 期号:11 页码:1212-1216
关键词	deconvolution oral absorption first-pass metabolism microcapsule aspirin
ISSN号	0918-6158
文献子类	Article
英文摘要	We have previously proposed a novel deconvolution method, which can estimate first-pass metabolism of orally administered drugs, In the present study, we examined whether this deconvolution method is useful for evaluating oral dosage forms. The absorption and first-pass metabolism of orally administered aspirin formulated in several forms were analyzed, Two types of microcapsules consisting of Eudragit L100 alone and Eudragit L100/ethylcellulose (4:6) were prepared as sustained release formulations, for comparison with aspirin in powder form. The deconvolution analysis revealed that: absorption of aspirin was sustained by encapsulating it in microcapsules, Interestingly, it also revealed that the percentage metabolized during absorption was different among the three types of formulations, Thus, the deconvolution method has enabled a comprehensive analysis of orally administered drugs. This method is believed to contribute to the evaluation of oral drug formulations.
学科主题	Pharmacology & Pharmacy
出版地	TOKYO
语种	英语
WOS记录号	WOS:000083819900013
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125932]
专题	第一临床医学院_期刊论文
通讯作者	Hashida, M (reprint author), Kyoto Univ, Grad Sch Pharmaceut Sci, Dept Drug Delivery Res, Sakyo Ku, Yoshida Shimoadachi Cho, Kyoto 60608501, Japan.
推荐引用方式 GB/T 7714	Wu, XN,Yamashita, F,Hashida, M,et al. Deconvolution analysis for absorption and metabolism of aspirin in microcapsules[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,1999,22(11):1212-1216.
APA	Wu, XN,Yamashita, F,Hashida, M,&Hashida, M .(1999).Deconvolution analysis for absorption and metabolism of aspirin in microcapsules.BIOLOGICAL & PHARMACEUTICAL BULLETIN,22(11),1212-1216.
MLA	Wu, XN,et al."Deconvolution analysis for absorption and metabolism of aspirin in microcapsules".BIOLOGICAL & PHARMACEUTICAL BULLETIN 22.11(1999):1212-1216.