Impact of drug-eluting stents with different coating strategies on stent thrombosis: A meta-analysis of 19 randomized trials

doi:10.5603/CJ.a2014.0002

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	Impact of drug-eluting stents with different coating strategies on stent thrombosis: A meta-analysis of 19 randomized trials
	Niu, XW; Yang, CL; Chen, D; He, SL; Yan, D; Yao, YL; Yao, YL (reprint author), Lanzhou Univ, Hosp 1, Dept Cardiol, 1 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
刊名	CARDIOLOGY JOURNAL
	2014
卷号	21 期号:5 页码:557-568
关键词	drug-eluting stents biodegradable polymers permanent polymers stent thrombosis meta-analysis
ISSN号	1897-5593
DOI	10.5603/CJ.a2014.0002
文献子类	Article
英文摘要	Background: Whether drug-eluting stents with biodegradable polymers (BP-DES) improve safety, especially with respect to stent thrombosis (ST) compared with permanent polymers DES (PP-DES), remains uncertain. We aimed to compare the short-and long-term outcomes and the ST risk in patients treated with BP-DES vs. PP-DES. Methods: We searched Medline, Embase, Web of science, CENTRAL databases, and conference proceedings/abstracts for randomized controlled trials (RCTs) comparing BP-DES with PP-DES. The primary endpoint was to compare the risks of overall and different temporal categories of definite/probable ST. Other clinical outcomes were target lesion revascularization (TLR), myocardial infarction (MI), and all-cause death in short-term (<= 1 year) and long-term follow-up. The meta-analyses were performed by computing odds ratios (ORs) with 95% confidence intervals (CIs) using a random-effects model. Results: Nineteen RCTs including 20,229 patients were analyzed. Overall, BP-DES significantly decreased the risks of very late definite/probable ST (OR 0.33; 95% CI 0.16-0.70), and TLR in long-term follow-up (OR 0.70; 95% CI 0.52-0.95) compared with PP-DES. There were no significant differences between the groups regarding MI incidence and mortality during both short and long follow-up periods. In stratified analyses, the long-term superiority of BP-DES was maintained only by using first-generation DES as the comparators. Conclusions: The present meta-analysis indicated that BP-DES were more efficacious than PP-DES at reducing the risks of very late ST and long-term TLR, but it could vary by heterogeneities in the use of PP-DES comparators. Additional rigorous RCTs with longer follow-up periods are warranted to verify these very promising long-term endpoints.
学科主题	Cardiovascular System & Cardiology
出版地	GDANSK
语种	英语
WOS记录号	WOS:000345995800015
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125923]
专题	第一临床医学院_期刊论文
通讯作者	Yao, YL (reprint author), Lanzhou Univ, Hosp 1, Dept Cardiol, 1 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Niu, XW,Yang, CL,Chen, D,et al. Impact of drug-eluting stents with different coating strategies on stent thrombosis: A meta-analysis of 19 randomized trials[J]. CARDIOLOGY JOURNAL,2014,21(5):557-568.
APA	Niu, XW.,Yang, CL.,Chen, D.,He, SL.,Yan, D.,...&Yao, YL .(2014).Impact of drug-eluting stents with different coating strategies on stent thrombosis: A meta-analysis of 19 randomized trials.CARDIOLOGY JOURNAL,21(5),557-568.
MLA	Niu, XW,et al."Impact of drug-eluting stents with different coating strategies on stent thrombosis: A meta-analysis of 19 randomized trials".CARDIOLOGY JOURNAL 21.5(2014):557-568.