GOLPH3 high expression predicts poor prognosis in patients with resected non-small cell lung cancer: an immunohistochemical analysis

doi:10.1007/s13277-014-2357-3

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	GOLPH3 high expression predicts poor prognosis in patients with resected non-small cell lung cancer: an immunohistochemical analysis
	Zhang, Y; Ma, MJ; Han, B; Han, B (reprint author), Lanzhou Univ, Hosp 1, Dept Thorac Surg, Lanzhou 730000, Gansu, Peoples R China.
刊名	TUMOR BIOLOGY
	2014-11
卷号	35 期号:11 页码:10833-10839
关键词	GOLPH3 Non-small cell lung cancer Prognosis
ISSN号	1010-4283
DOI	10.1007/s13277-014-2357-3
文献子类	Article
英文摘要	Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human tumours. However, little is known about GOLPH3 expression and its clinical significance in non-small cell lung cancer (NSCLC). The present study was conducted to investigate the expression of GOLPH3 and its prognostic significance in NSCLC. Immunohistochemical analysis was used to determine the expression of GOLPH3 in 145 cases NSCLC tissue and their corresponding adjacent normal tissues. The results are the following: (1) The GOLPH3 protein was mainly located in the cytoplasm of NSCLC tissue; (2) GOLPH3 was highly expressed in 71.7 % of NSCLC tissues versus 22.8 % of adjacent tissues (P < 0.01); (3) GOLPH3 expression was significantly associated with tumour-node-metastasis (TNM) stage (P = 0.001), lymph node status (P = 0.014), and degree of differentiation (P = 0.018); (4) The Kaplan-Meier curve indicated that the patients with high GOLPH3 expression had significantly shorter survival than those with low GOLPH3 expression; and (5) Cox regression analysis demonstrated that the expression of GOLPH3, lymph node status, and TNM stage were independent prognostic predictors for NSCLC patients. High GOLPH3 expression is predictive of poor prognosis of NSCLC, implying that GOLPH3 may be a promising new target for targeted therapies for NSCLC.
学科主题	Oncology
出版地	DORDRECHT
语种	英语
WOS记录号	WOS:000345413100027
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125909]
专题	第一临床医学院_期刊论文
通讯作者	Han, B (reprint author), Lanzhou Univ, Hosp 1, Dept Thorac Surg, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, Y,Ma, MJ,Han, B,et al. GOLPH3 high expression predicts poor prognosis in patients with resected non-small cell lung cancer: an immunohistochemical analysis[J]. TUMOR BIOLOGY,2014,35(11):10833-10839.
APA	Zhang, Y,Ma, MJ,Han, B,&Han, B .(2014).GOLPH3 high expression predicts poor prognosis in patients with resected non-small cell lung cancer: an immunohistochemical analysis.TUMOR BIOLOGY,35(11),10833-10839.
MLA	Zhang, Y,et al."GOLPH3 high expression predicts poor prognosis in patients with resected non-small cell lung cancer: an immunohistochemical analysis".TUMOR BIOLOGY 35.11(2014):10833-10839.