Age, estimated glomerular filtration rate and ejection fraction score predicts contrast-induced acute kidney injury in patients with diabetes and chronic kidney disease: insight from the TRACK-D study

doi:10.3760/cma.j.issn.0366-6999.20133154

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	Age, estimated glomerular filtration rate and ejection fraction score predicts contrast-induced acute kidney injury in patients with diabetes and chronic kidney disease: insight from the TRACK-D study
	Li, J; Li, Y; Wang, XZ; Yang, SG; Gao, CY; Zhang, Z; Yang, CM; Jing, QM; Wang, SL; Ma, YY
刊名	CHINESE MEDICAL JOURNAL
	2014-06-20
卷号	127 期号:12 页码:2332-2336
关键词	AGEF score contrast induced acute kidney injury diabetes chronic kidney disease
ISSN号	0366-6999
DOI	10.3760/cma.j.issn.0366-6999.20133154
文献子类	Article
英文摘要	Background The occurrence of contrast induced acute kidney injury (CIAKI) has a pronounced impact on morbidity and mortality. The aim of the present study was to appraise the diagnostic efficacy of age, estimated glomerular filtration rate (eGFR) and ejection fraction (AGEF) score (age/EF(%)+1 (if eGFR was <60 ml.min(-1).1.73 m(-2))) as an predictor of CIAKI in patients with diabetes mellitus (DM) and concomitant chronic kidney disease (CKD). Methods The AGEF score was calculated for 2 998 patients with type 2 DM and concomitant CKD who had undergone coronary/peripheral arterial angiography. CIAKI was defined as an increase in sCr concentration of 0.5 mg/dl (44.2 mmol/L) or 25% above baseline at 72 hours after exposure to the contrast medium. Post hoc analysis was performed by stratifying the rate of CIAKI according to AGEF score tertiles. The diagnostic efficacy of the AGEF score for predicting CIAKI was evaluated with receiver operating characteristic (ROC) analysis. Results The AGEF score ranged from 0.49 to 3.09. The AGEF score tertiles were defined as follows: AGEF(low) <= 0.92 (n=1 006); 0.92 1.16 (n=992). The incidence of CIAKI was significantly different in patients with low, middle and high AGEF scores (AGEF(low)=1.1%, AGEF(mid)=2.3% and AGEF(high)=5.8%, P <0.001). By multivariate analysis, AGEF score was an independent predictor of CIAKI (odds ratio=4.96, 95% Cl: 2.32-10.58, P <0.01). ROC analysis showed that the area under the curve was 0.70 (95% CI: 0.648-0.753, P <0.001). Conclusion The AGEF score is effective for stratifying risk of CIAKI in patients with DM and CKD undergoing coronary/peripheral arterial angiography.
学科主题	General & Internal Medicine
出版地	BEIJING
资助项目	国家科技重大专项
项目编号	Key technologies R&D project of Liaoning Province [2013225089] ; Key Project of National 12th Five-Year Research Program of China [2012ZX09303016-002]
语种	英语
CSCD记录号	CSCD:5173793
WOS记录号	WOS:000339220700025
资助机构	MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125871]
专题	第一临床医学院_期刊论文
通讯作者	Han, YL (reprint author), Shenyang Northern Hosp, Dept Cardiol, Shenyang 110016, Liaoning, Peoples R China.
推荐引用方式 GB/T 7714	Li, J,Li, Y,Wang, XZ,et al. Age, estimated glomerular filtration rate and ejection fraction score predicts contrast-induced acute kidney injury in patients with diabetes and chronic kidney disease: insight from the TRACK-D study[J]. CHINESE MEDICAL JOURNAL,2014,127(12):2332-2336.
APA	Li, J.,Li, Y.,Wang, XZ.,Yang, SG.,Gao, CY.,...&Han, YL .(2014).Age, estimated glomerular filtration rate and ejection fraction score predicts contrast-induced acute kidney injury in patients with diabetes and chronic kidney disease: insight from the TRACK-D study.CHINESE MEDICAL JOURNAL,127(12),2332-2336.
MLA	Li, J,et al."Age, estimated glomerular filtration rate and ejection fraction score predicts contrast-induced acute kidney injury in patients with diabetes and chronic kidney disease: insight from the TRACK-D study".CHINESE MEDICAL JOURNAL 127.12(2014):2332-2336.