Meta-Analysis on the Relationship between HLA-DRBl Gene Polymorphism and Cervical Cancer in Chinese Population

doi:10.1371/journal.pone.0088439

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	Meta-Analysis on the Relationship between HLA-DRBl Gene Polymorphism and Cervical Cancer in Chinese Population
	Wei, LZ; Wang, HL; Liu, X; Lu, YP; Xu, F; Yuan, JQ; Ling, YQ; Wang, HL (reprint author), Gansu Prov Hosp, Dept Obstet & Gynecol, Lanzhou, Gansu, Peoples R China.
刊名	PLOS ONE
	2014-02-14
卷号	9 期号:2 页码:-
ISSN号	1932-6203
DOI	10.1371/journal.pone.0088439
文献子类	Article
英文摘要	Aim: To determine the association between HLA-DRB1 haplotypes and risk of cervical cancer in unselected and samples from Chinese ethnicities. Methods: A comprehensive search for articles from their inception to April 1st, 2013 was conducted from PubMed, Medline, Elsevier Science, Springer Link, Cochrane Library database, China biology medical literature database (CBM), China National Knowledge Infrastructure (CNKI), VIP, and Chinese literature database(Wang fang). A total of 1596 patients with cervical cancer and 2048 controls from the 12 studies on the relationship between gene polymorphism of HLA-DRB l and cervical cancer were performed and data were analyzed and processed using Review Manager 5.0 and Stata 11.0. Results: Among the 13 family alleles, two (DRB1* 03 and DRB1* 08) were found to be negatively associated with cervical cancer in all studies or in Uighur subgroups, and two (DRB1* 10 and DRB1* 15) were positively associated with in all studies or in Uighur subgroups. Among the 25 specific alleles, six (DRB1* 0301, * 0403,* 0404, * 0803, * 1312 and * 1502) were associated with an increased risk cervical cancer in all studies. No significant association was established for other HLA-DRB1 family alleles and specific alleles. Ethnicity partially explained the race influence of DRB1* 12, DRB1* 14, DRB1* 0301, DRB1* 0403, DRB1* 0404, DRB1* 0803, DRB1* 1312 and DRB1* 1502 phenotypes. Conclusion: Our results support the hypothesis that the HLA-DRB1 family alleles and specific alleles might influence the susceptibility or resistance to cervical cancer, suggesting that immune regulation may play a key role in this disease, although further investigations are still needed.
学科主题	Science & Technology - Other Topics
出版地	SAN FRANCISCO
语种	英语
WOS记录号	WOS:000331271500037
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125828]
专题	第一临床医学院_期刊论文
通讯作者	Wang, HL (reprint author), Gansu Prov Hosp, Dept Obstet & Gynecol, Lanzhou, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Wei, LZ,Wang, HL,Liu, X,et al. Meta-Analysis on the Relationship between HLA-DRBl Gene Polymorphism and Cervical Cancer in Chinese Population[J]. PLOS ONE,2014,9(2):-.
APA	Wei, LZ.,Wang, HL.,Liu, X.,Lu, YP.,Xu, F.,...&Wang, HL .(2014).Meta-Analysis on the Relationship between HLA-DRBl Gene Polymorphism and Cervical Cancer in Chinese Population.PLOS ONE,9(2),-.
MLA	Wei, LZ,et al."Meta-Analysis on the Relationship between HLA-DRBl Gene Polymorphism and Cervical Cancer in Chinese Population".PLOS ONE 9.2(2014):-.