Stearylated antimicrobial peptide [D]-K6L9 with cell penetrating property for efficient gene transfer

doi:10.1016/j.peptides.2013.05.011

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	Stearylated antimicrobial peptide [D]-K6L9 with cell penetrating property for efficient gene transfer
	Zhang, W; Song, JJ; Liang, RR; Zheng, X; Chen, JB; Li, GL; Zhang, BZ; Wang, KR; Yan, X; Wang, R
刊名	PEPTIDES
	2013-08
卷号	46 页码:33-39
关键词	Nonviral gene vector Stearylation Cell penetrating peptide Antimicrobial peptide Endocytosis
ISSN号	0196-9781
DOI	10.1016/j.peptides.2013.05.011
文献子类	Article
英文摘要	Stearyl-cell penetrating peptides (CPPs) have been proved to be efficient nonviral gene vectors. Due to the similarities between antimicrobial peptides and CPPs, we constructed a novel type of gene vectors by introducing stearyl moiety to the N-terminus of antimicrobial peptide [D]-K6L9. In this study, stearyl-[D]-K6L9 delivered plasmids into cells by clathrin- and caveolin-mediated endocytosis. Gratifyingly, stearyl-[D]-K6L9 exhibited high transfection efficiency and almost reached the level of Lipofectamine 2000. Taken together, the combination of the stearyl moiety with [D]-K6L9 provides a novel framework for the development of excellent nonviral gene vectors. (C) 2013 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
出版地	NEW YORK
资助项目	国家自然科学基金项目 ; 国家科技重大专项 ; 中国博士后科学基金
项目编号	National Natural Science Foundation of China [91213302, 20932003, 21272102] ; Ministry of Science and Technology of China [2012ZX09504-001-003] ; China Postdoctoral Science Foundation [2012M512047]
语种	英语
WOS记录号	WOS:000322628600006
资助机构	NSFC ; MOST ; CPSF
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125800]
专题	第一临床医学院_期刊论文
通讯作者	Yan, X (reprint author), Lanzhou Univ, Clin Med Sch 1, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, W,Song, JJ,Liang, RR,et al. Stearylated antimicrobial peptide [D]-K6L9 with cell penetrating property for efficient gene transfer[J]. PEPTIDES,2013,46:33-39.
APA	Zhang, W.,Song, JJ.,Liang, RR.,Zheng, X.,Chen, JB.,...&Yan, X .(2013).Stearylated antimicrobial peptide [D]-K6L9 with cell penetrating property for efficient gene transfer.PEPTIDES,46,33-39.
MLA	Zhang, W,et al."Stearylated antimicrobial peptide [D]-K6L9 with cell penetrating property for efficient gene transfer".PEPTIDES 46(2013):33-39.