Prevalence of human metapneumovirus in children with acute lower respiratory infection in Changsha, China

doi:10.1002/jmv.23501

CORC > 兰州大学 > 兰州大学 > 第一临床医学院 > 期刊论文

	Prevalence of human metapneumovirus in children with acute lower respiratory infection in Changsha, China
	Xiao, NG; Zhang, B; Xie, ZP; Zhou, QH; Zhang, RF; Zhong, LL; Ding, XF; Li, J; Song, JR; Gao, HC
刊名	JOURNAL OF MEDICAL VIROLOGY
	2013-03
卷号	85 期号:3 页码:546-553
关键词	acute lower respiratory infection children hMPV reverse transcription-polymerase chain reaction
ISSN号	0146-6615
DOI	10.1002/jmv.23501
文献子类	Article
英文摘要	Human metapneumovirus (hMPV) causes acute respiratory infections in children. The prevalence and clinical characteristics of hMPV were determined in nasopharyngeal aspirates of children in Changsha, China. Reverse transcription-polymerase chain reaction (RT-PCR) or PCR was employed to screen for both hMPV and other common respiratory viruses in 1,165 nasopharyngeal aspirate specimens collected from children with lower respiratory tract infections from September 2007 to August 2008. All PCR products were sequenced, and demographic and clinical data were collected from all patients. Seventy-six of 1,165 (6.5%) specimens were positive for hMPV, of which 85.5% (65/76) occurred in the winter and spring seasons. The hMPV coinfection rate was 57.9% (44/76), and human bocavirus was the most common virus detected in conjunction with hMPV. Phylogenetic analysis revealed that 94.7% of the hMPV detected were of subgroup A2, 5.3% were subgroup B2, and none belonged to either the A1 or B1 subgroups. No significant differences were found in terms of the frequency of diagnosis and clinical signs between either the co- and mono-infection groups, or between patients with and without underlying diseases. It was concluded that hMPV is an important viral pathogen in pediatric patients with lower respiratory tract infections in Changsha. Only hMPV genotypes A2 and B2 were co-circulating in this locality; human bocavirus was the most common coinfecting virus, and coinfection did not affect disease severity. J. Med. Virol. 85:546553, 2013. (c) 2013 Wiley Periodicals, Inc.
学科主题	Virology
出版地	HOBOKEN
资助项目	国家自然科学基金项目
项目编号	Hunan Provincial Natural Science Foundation of China [07JJ5055]
语种	英语
WOS记录号	WOS:000313946600024
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125774]
专题	第一临床医学院_期刊论文
通讯作者	Duan, ZJ (reprint author), China CDC, Natl Inst Viral Dis Control & Prevent, 100 Ying Xin St, Beijing 100052, Peoples R China.
推荐引用方式 GB/T 7714	Xiao, NG,Zhang, B,Xie, ZP,et al. Prevalence of human metapneumovirus in children with acute lower respiratory infection in Changsha, China[J]. JOURNAL OF MEDICAL VIROLOGY,2013,85(3):546-553.
APA	Xiao, NG.,Zhang, B.,Xie, ZP.,Zhou, QH.,Zhang, RF.,...&Duan, ZJ .(2013).Prevalence of human metapneumovirus in children with acute lower respiratory infection in Changsha, China.JOURNAL OF MEDICAL VIROLOGY,85(3),546-553.
MLA	Xiao, NG,et al."Prevalence of human metapneumovirus in children with acute lower respiratory infection in Changsha, China".JOURNAL OF MEDICAL VIROLOGY 85.3(2013):546-553.