Lafutidine-based Triple Therapy for Helicobacter pylori Eradication

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	Lafutidine-based Triple Therapy for Helicobacter pylori Eradication
	Ren, QA; Ma, B; Yang, KH; Yan, XA; Yan, XA (reprint author), Lanzhou Univ, Hosp 1, 1 DongGang W Rd, Lanzhou 730000, Peoples R China.
刊名	HEPATO-GASTROENTEROLOGY
	2010-09
卷号	57 期号:102-03 页码:1074-1081
关键词	Lafutidine Helicobacter pylori Eradication Triple therapy Meta-analysis
ISSN号	0172-6390
文献子类	Article
英文摘要	Background/Aims: For treating Helicobacter pylori infection, it is still debatable whether proton pump inhibitor can be replaced by H-2-receptor antagonist without compromising efficacy. Lafutidine is a newly synthesized H-2-receptor antagonist and has been shown to exhibit antisecretory action. This meta-analysis investigated the efficacy of lafutidine-based triple therapy for Helicobacter pylori infection. Methodogy: We searched PUBMED; EMBASE, the Cochrane Library and Chinese Biomedical Database databases to identify randomized controlled trials regarding lafutidine-based triple therapy of Helicobacter pylori eradication. Results: Thirteen potential studies were retrieved, of which 3 met our inclusion criteria. Overall we observed Helicobacter pylori eradication rates were similar in the lafutidine group and the lansoprazole group (OR, 1.03; 95% CI, 0.64-1.66). The OR for the active stage ulcer cure rate was 0.78 (95% CI, 0.35, 1.71) for lafutidine-based triple therapy compared with lansoprazole-based triple therapy. Likewise, we observed symptom response and adverse events were similar in both groups. Conclusions: Lafutidine-based triple therapy was as safe and effective as triple therapy including lansoprazole for Helicobacter pylori infection, and could be considered as an additional treatment option. However, more rigorous research is required to accurately assess the role of lafutidine in eradicating Helicobacter pylori infection.
学科主题	Gastroenterology & Hepatology ; Surgery
出版地	ATHENS
语种	英语
WOS记录号	WOS:000286564100014
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125714]
专题	第一临床医学院_期刊论文
通讯作者	Yan, XA (reprint author), Lanzhou Univ, Hosp 1, 1 DongGang W Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Ren, QA,Ma, B,Yang, KH,et al. Lafutidine-based Triple Therapy for Helicobacter pylori Eradication[J]. HEPATO-GASTROENTEROLOGY,2010,57(102-03):1074-1081.
APA	Ren, QA,Ma, B,Yang, KH,Yan, XA,&Yan, XA .(2010).Lafutidine-based Triple Therapy for Helicobacter pylori Eradication.HEPATO-GASTROENTEROLOGY,57(102-03),1074-1081.
MLA	Ren, QA,et al."Lafutidine-based Triple Therapy for Helicobacter pylori Eradication".HEPATO-GASTROENTEROLOGY 57.102-03(2010):1074-1081.