Prevalence and clinical characteristics of human CoV-HKU1 in children with acute respiratory tract infections in China

doi:10.1016/j.jcv.2010.07.002

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	Prevalence and clinical characteristics of human CoV-HKU1 in children with acute respiratory tract infections in China
	Jin, Y; Song, JR; Xie, ZP; Gao, HC; Yuan, XH; Xu, ZQ; Yan, KL; Zhao, Y; Xiao, NG; Hou, YD
刊名	JOURNAL OF CLINICAL VIROLOGY
	2010-10
卷号	49 期号:2 页码:126-130
关键词	Acute respiratory tract infection HCoV-HKU1 Reverse transcription polymerase chain reaction Children
ISSN号	1386-6532
DOI	10.1016/j.jcv.2010.07.002
文献子类	Article
英文摘要	Background: Human CoV-HKU1 (HCoV-HKU1) has been isolated from a 71-year-old man with pneumonia; however, the impact and role of emerging HCoV-HKU1 have not been defined in children with acute respiratory tract infection (ARTI). Objective: To investigate the Prevalence and clinical characteristics of HCoV-HKU1 in children with ARTI in Lanzhou, China. Study design: The reverse transcription polymerase chain reaction (RT-PCR) or PCR was employed to screen HCoV-HKU1 and other common respiratory viruses in 645 nasopharyngeal aspirate (NPA) specimens collected from children with ARTI from November 2006 to October 2008. All PCR positive products were sequenced. And the demographic and clinical data were collected for all patients. Results: Nineteen of 645 (2.95%) specimens tested positive for HCoV-HKU1, and all HCoV-HKU1 positive specimens were distributed in the winter and spring season. The HCoV-HKU1 co-infection rate with other respiratory viruses was 47.37% (9/19). There was no statistically significant difference in the detection rate between groups by age or gender, except between patients with and without underlying diseases. The phylogenetic analysis indicated that HCoV-HKU1 genotype B was circulating in the years 2007 and 2008 in children with ARTI in Lanzhou, China. Conclusions: HCoV-HKU1 is an uncommon virus existing among Chinese children with ARTI. Children with underlying diseases are more vulnerable to viral infection. Only HCoV-HKU1 genotype B circulated locally. (C) 2010 Published by Elsevier B.V.
学科主题	Virology
出版地	AMSTERDAM
资助项目	国家重点基础研究发展计划以及国家重大科学研究计划（973计划） ; 国家科技重大专项
项目编号	973 National Key Basic Research Program of China [2007CB310500] ; China Mega-Project for Infectious Disease [2009ZX10004-001]
语种	英语
WOS记录号	WOS:000281917600011
资助机构	MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125706]
专题	第一临床医学院_期刊论文
通讯作者	Duan, ZJ (reprint author), China CDC, Dept Viral Diarrhea, Natl Inst Viral Dis Control & Prevent, State Key Lab Mol Virol & Genet Engn, 100 Ying Xin St, Beijing 100052, Peoples R China.
推荐引用方式 GB/T 7714	Jin, Y,Song, JR,Xie, ZP,et al. Prevalence and clinical characteristics of human CoV-HKU1 in children with acute respiratory tract infections in China[J]. JOURNAL OF CLINICAL VIROLOGY,2010,49(2):126-130.
APA	Jin, Y.,Song, JR.,Xie, ZP.,Gao, HC.,Yuan, XH.,...&Duan, ZJ .(2010).Prevalence and clinical characteristics of human CoV-HKU1 in children with acute respiratory tract infections in China.JOURNAL OF CLINICAL VIROLOGY,49(2),126-130.
MLA	Jin, Y,et al."Prevalence and clinical characteristics of human CoV-HKU1 in children with acute respiratory tract infections in China".JOURNAL OF CLINICAL VIROLOGY 49.2(2010):126-130.