Human Bocavirus Infection in Young Children With Acute Respiratory Tract Infection in Lanzhou, China

doi:10.1002/jmv.21689

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	Human Bocavirus Infection in Young Children With Acute Respiratory Tract Infection in Lanzhou, China
	Zheng, LS; Yuan, XH; Xie, ZP; Jin, Y; Gao, HC; Song, JR; Zhang, RF; Xu, ZQ; Hou, YD; Duan, ZJ
刊名	JOURNAL OF MEDICAL VIROLOGY
	2010-02
卷号	82 期号:2 页码:282-288
关键词	human bocavirus acute respiratory tract infection coinfection children
ISSN号	0146-6615
DOI	10.1002/jmv.21689
文献子类	Article
英文摘要	Human bocavirus (HBoV) is a recognized human parvovirus associated with acute respiratory tract infection. However, HBoV has yet to be established as a causative agent of respiratory disease. In this study, the epidemiological and virological characteristics of HBoV infection were studied in children with acute respiratory tract infection in China. In total, 406 children younger than 14 years of age with acute respiratory tract infection were included in this prospective 1-year study. HBoV was detected in 29 (7.1%) of the 406 children. No clear seasonal fluctuation was observed in infection rates of HBoV. Of the 29 children infected with HBoV, 16 (55.2%) were coinfected with other respiratory viruses, most commonly respiratory syncytial virus (RSV). Viral coinfection with HBoV did not affect the severity of the respiratory disease (P=0.291). The number of HBoV genome copies ranged from 5.80 x 10(2) to 9.72 x 10(8) cop-copies/ml in nasopharyngeal aspirates among HBoV-positive specimens by real-time PCR, and neither coinfection nor the severity of disease correlated with the viral load (P=0.148, P=0.354, respectively). The most common clinical features were cough and acute upper respiratory infection, and acute bronchopneumonia. Additionally, the NP-1 gene of HBoV showed minimal sequence variation. These data suggest that HBoV is frequent in young children with acute respiratory tract infection in Lanzhou, China, and RSV is the most common coinfecting virus. There was no apparent association between the viral load of HBoV and coinfection or disease severity. The NP-1 gene was highly conserved in HBoV. J. Med. Virol. 82:282-288, 2010. (C) 2009 Wiley-Liss, Inc.
学科主题	Virology
出版地	HOBOKEN
资助项目	国家自然科学基金项目
项目编号	National Natural Science Foundation of China [30600682]
语种	英语
WOS记录号	WOS:000273374500013
资助机构	NSFC
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125693]
专题	第一临床医学院_期刊论文
通讯作者	Duan, ZJ (reprint author), China CDC, Natl Inst Viral Dis Control & Prevent, State Key Lab Mol Virol & Genet Engn, 100 Ying Xin St, Beijing 100052, Peoples R China.
推荐引用方式 GB/T 7714	Zheng, LS,Yuan, XH,Xie, ZP,et al. Human Bocavirus Infection in Young Children With Acute Respiratory Tract Infection in Lanzhou, China[J]. JOURNAL OF MEDICAL VIROLOGY,2010,82(2):282-288.
APA	Zheng, LS.,Yuan, XH.,Xie, ZP.,Jin, Y.,Gao, HC.,...&Duan, ZJ .(2010).Human Bocavirus Infection in Young Children With Acute Respiratory Tract Infection in Lanzhou, China.JOURNAL OF MEDICAL VIROLOGY,82(2),282-288.
MLA	Zheng, LS,et al."Human Bocavirus Infection in Young Children With Acute Respiratory Tract Infection in Lanzhou, China".JOURNAL OF MEDICAL VIROLOGY 82.2(2010):282-288.