Improving the Dissolution and Oral Bioavailability of the Poorly Water-soluble Drug Aloe-Emodin by Solid Dispersion With Polyethylene Glycol 6000

doi:10.1002/ddr.20312

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	Improving the Dissolution and Oral Bioavailability of the Poorly Water-soluble Drug Aloe-Emodin by Solid Dispersion With Polyethylene Glycol 6000
	Duan, HG; Wei, YH; Li, BX; Qin, HY; Wu, XA; Wu, XA (reprint author), Lanzhou Univ, Hosp 1, Dept Pharm, Lanzhou 730000, Peoples R China.
刊名	DRUG DEVELOPMENT RESEARCH
	2009-08
卷号	70 期号:5 页码:363-369
关键词	dissolution oral bioavailability aloe-emodin solid dispersion polyethylene glycol 6000
ISSN号	0272-4391
DOI	10.1002/ddr.20312
文献子类	Article
英文摘要	Solid dispersions (SDs) of aloe-emodin (AE) and polyethylene glycol 6000 (PEG6000) with different drug loadings were prepared, characterized by scanning electron microscopy (SEM) and differential scanning calorimetry (DSc) and evaluated for solubility and in vitro release. The oral bioavailability of AE from SD in rats was compared with the crystalline drug. Plasma concentrations of AE were determined by HPLC. After administration of crystalline AE (35 mg . kg(-1)) in rats, the AUC(0-600) and C(max) were 393.6 +/- 77.1 mg.min.l(-1) and 1.87 +/- 0.30 mg.l(-1), respectively. For the PEG6000 SD of AE, AUC(0-600) and C(max) were boosted to 1310.5 +/- 111.9 mg.l(-1) and 5.86 +/- 0.47 mg.l(-1), respectively. The results indicated that the oral bioavailability of AE was increased significantly. Simultaneously, the T(max) value of AE for AE crystalline was decreased from 75.6 +/- 17.3 min to 44.8 +/- 14.8 min for SD. The earlier T(max) for AE from SD indicated the higher extent of absorption for SD due to their improved dissolution rate in rat intestine. This SD approach can therefore be used to enhanced dissolution and bioavailability for poorly water-soluble drugs. Drug Dev Res 70:363-369, 2009. (C) 2009 Wiley-Liss, Inc.
学科主题	Pharmacology & Pharmacy
出版地	HOBOKEN
语种	英语
WOS记录号	WOS:000268433400002
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125682]
专题	第一临床医学院_期刊论文
通讯作者	Wu, XA (reprint author), Lanzhou Univ, Hosp 1, Dept Pharm, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Duan, HG,Wei, YH,Li, BX,et al. Improving the Dissolution and Oral Bioavailability of the Poorly Water-soluble Drug Aloe-Emodin by Solid Dispersion With Polyethylene Glycol 6000[J]. DRUG DEVELOPMENT RESEARCH,2009,70(5):363-369.
APA	Duan, HG,Wei, YH,Li, BX,Qin, HY,Wu, XA,&Wu, XA .(2009).Improving the Dissolution and Oral Bioavailability of the Poorly Water-soluble Drug Aloe-Emodin by Solid Dispersion With Polyethylene Glycol 6000.DRUG DEVELOPMENT RESEARCH,70(5),363-369.
MLA	Duan, HG,et al."Improving the Dissolution and Oral Bioavailability of the Poorly Water-soluble Drug Aloe-Emodin by Solid Dispersion With Polyethylene Glycol 6000".DRUG DEVELOPMENT RESEARCH 70.5(2009):363-369.