Involvement of tumor suppressor in lung cancer 1 gene expression in cervical carcinogenesis

doi:10.1111/j.1525-1438.2006.00656.x

CORC > 兰州大学 > 兰州大学 > 第一临床医学院 > 期刊论文

	Involvement of tumor suppressor in lung cancer 1 gene expression in cervical carcinogenesis
	Yang, YX; Yang, AH; Yang, ZJ; Wang, ZR; Xia, XH; Yang, ZJ (reprint author), 1289 Yishan Rd, Shanghai 200233, Peoples R China.
刊名	INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
	2006-09
卷号	16 期号:5 页码:1868-1872
关键词	carcinogenesis cervical cancer gene expression TSLC1
ISSN号	1048-891X
DOI	10.1111/j.1525-1438.2006.00656.x
文献子类	Article
英文摘要	Tumor suppressor in lung cancer 1 (TSLC1) is a tumor suppressor gene in non-small cell lung cancer, and loss of TSLC1 gene expression has been observed in a number of epithelial carcinomas and cancer-derived cell lines. We analyzed TSLC1 gene expression by real-time reverse transcription-polymerase chain reaction in 39 invasive cervical carcinomas, 34 cervical intraepithelial neoplasia (CIN) IIIs, 35 CIN IIs, 32 CIN I, 36 inflammation cervical tissues, and 30 normal cervix samples. Loss of TSLC1 gene expression was observed in 30 of 39 (77%) cervical carcinomas, 25 of 34 (73%) CIN IIIs, 9 of 35 (26%) CIN IIs, and 7 of 32 (22%) CIN Is but was not found in inflammation and normal cervix samples. Compared to normal cervical tissue, loss of TSLC1 gene was significantly high in CIN IIIs and cervical cancer (P = 0.00). Moreover, loss of TSLC1 gene expression is observed at a significantly higher frequency in CIN IIIs and cervical cancers than in CIN IIs (P < 0.05). The results show that loss of TSLC1 gene expression is an early event in cervical carcinogenesis and often accompanies invasive cervical cancers.
学科主题	Oncology ; Obstetrics & Gynecology
出版地	OXFORD
语种	英语
WOS记录号	WOS:000240824100022
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/125657]
专题	第一临床医学院_期刊论文
通讯作者	Yang, ZJ (reprint author), 1289 Yishan Rd, Shanghai 200233, Peoples R China.
推荐引用方式 GB/T 7714	Yang, YX,Yang, AH,Yang, ZJ,et al. Involvement of tumor suppressor in lung cancer 1 gene expression in cervical carcinogenesis[J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,2006,16(5):1868-1872.
APA	Yang, YX,Yang, AH,Yang, ZJ,Wang, ZR,Xia, XH,&Yang, ZJ .(2006).Involvement of tumor suppressor in lung cancer 1 gene expression in cervical carcinogenesis.INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER,16(5),1868-1872.
MLA	Yang, YX,et al."Involvement of tumor suppressor in lung cancer 1 gene expression in cervical carcinogenesis".INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 16.5(2006):1868-1872.