The effects of x-ray radiation on the eye development of zebrafish

doi:10.1177/0960327114522278

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	The effects of x-ray radiation on the eye development of zebrafish
	Zhou, R; Si, J; Zhang, H; Wang, Z; Li, J; Zhou, X; Can, L; Liu, Y; Zhang, H (reprint author), Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou 730000, Peoples R China.
刊名	HUMAN & EXPERIMENTAL TOXICOLOGY
	2014-10
卷号	33 期号:10 页码:1040-1050
关键词	X-Ray eye development zebrafish cell apoptosis reactive oxygen species microophthalmia
ISSN号	0960-3271
DOI	10.1177/0960327114522278
文献子类	Article
英文摘要	The toxic effects of x-ray radiation on eye development was measured using zebrafish as a model organism. Zebrafish embryos at 8 h post-fertilization (hpf) were irradiated using X-rays at doses of 1, 2, 4, and 8 Gy. At 24 and 48 hpf, x-ray radiation induced a significant increase in reactive oxygen species (ROS) content and cell apoptotic signals. Both of these increases were dose dependent and there were significant positive relationships between them at 24 hpf. At 48 and 72 hpf, the increase of ROS concentration can be eliminated by increasing activities of superoxide dismutase and catalase. Although the ROS generated by x-ray radiation caused a significant increase in cell apoptosis at 24 and 48 hpf, the cellular layers of the retina and lens formation in the irradiated groups were not significantly disrupted at 144 hpf compared with the control group, with the exception of a heterogeneous distribution of the cells in inner nuclear cell layer and a significant decrease in the diameters of whole eyes after 8 Gy irradiation. X-Ray radiation at later stages of gastrulation may not cause distinct optic complications; however, there is still a risk of microophthalmia at high doses of irradiation.
学科主题	Toxicology
出版地	LONDON
资助项目	国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划（973计划） ; 甘肃省青年科技基金计划 ; 甘肃省科技重大专项计划
项目编号	National Basic Research Program of China [2010CB834202] ; National Natural Science Foundation of China [10835011] ; Scientific Technology Research Projects of Gansu Province [0702NKDA045, 0806RJYA020]
语种	英语
WOS记录号	WOS:000343382400005
资助机构	NSFC ; MOST ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/122123]
专题	口腔医学院_期刊论文
通讯作者	Zhang, H (reprint author), Chinese Acad Sci, Inst Modern Phys, Dept Heavy Ion Radiat Med, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Zhou, R,Si, J,Zhang, H,et al. The effects of x-ray radiation on the eye development of zebrafish[J]. HUMAN & EXPERIMENTAL TOXICOLOGY,2014,33(10):1040-1050.
APA	Zhou, R.,Si, J.,Zhang, H.,Wang, Z.,Li, J.,...&Zhang, H .(2014).The effects of x-ray radiation on the eye development of zebrafish.HUMAN & EXPERIMENTAL TOXICOLOGY,33(10),1040-1050.
MLA	Zhou, R,et al."The effects of x-ray radiation on the eye development of zebrafish".HUMAN & EXPERIMENTAL TOXICOLOGY 33.10(2014):1040-1050.