Pharmacokinetics and tissue distribution of emodin loaded nanoemulsion in rats

doi:10.1016/j.jddst.2015.10.019

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	Pharmacokinetics and tissue distribution of emodin loaded nanoemulsion in rats
	Shi, YB; Li, JC; Ren, Y; Wang, HQ; Cong, ZT; Wu, GT; Du, LD; Li, HL; Zhang, XY; Shi, YB (reprint author), Lanzhou Univ, Sch Pharm, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.
刊名	JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
	2015-12
卷号	30 页码:242-249
关键词	Emodin loaded nanoemulsion Pharmacokinetics Tissue distribution
ISSN号	1773-2247
DOI	10.1016/j.jddst.2015.10.019
文献子类	Article
英文摘要	Emodin, a natural product originated from radix et rhizoma Rhei, is a potential agent for anti-constipation, anti-inflammation, anti-cancer and so on. In this paper, a simple, economic and sensitive HPLC-FD method was developed and validated for the determination of emodin in rat plasma and tissue homogenates after oral administration of emodin loaded nanoemulsion (EMO-NE). Simultaneously, the pharmacokinetics of EMO-NE and emodin suspension were investigated so as to embody advantages of EMO-NE. AUC(0-infinity), C-max, t(1/2) and MRT0-infinity, of emodin-loaded nanoemulsion were respectively 2.37, 1.62, 3.99 and 2.39-fold higher than those of emodin suspension. Meanwhile, EMO-NE decreased the clearance rate of emodin more than double that of emodin suspension. Thus, it can be assumed that EMO-NE can effectively improve the bioavailability of emodin and prolong in vivo mean residence time via oral administration. All tested tissues of rats were found to retain parent drug for 48 h following a single oral dose of EMO-NE. The amount of emodin was the highest in the liver, and then lung, kidney, heart or spleen, and lowest in the brain. However, the mean residence time of emodin in the brain was the longest, almost two-fold longer than that in the other tissues. (C) 2015 Elsevier B.V. All rights reserved.
学科主题	Pharmacology & Pharmacy
出版地	AMSTERDAM
资助项目	甘肃省自然科学基金计划
项目编号	Key Laboratory of TCM Pharmacology and Toxicology of Gansu Province [ZDSYS-KJ-2013-005] ; Natural Science Grant of Gansu [145RJZA026] ; Agricultural Biotechnology Research and Development Project of Gansu, P.R. China [GNSW-2013-14]
语种	英语
WOS记录号	WOS:000367773500028
资助机构	GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179570]
专题	药学院_期刊论文
通讯作者	Shi, YB (reprint author), Lanzhou Univ, Sch Pharm, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Shi, YB,Li, JC,Ren, Y,et al. Pharmacokinetics and tissue distribution of emodin loaded nanoemulsion in rats[J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,2015,30:242-249.
APA	Shi, YB.,Li, JC.,Ren, Y.,Wang, HQ.,Cong, ZT.,...&Shi, YB .(2015).Pharmacokinetics and tissue distribution of emodin loaded nanoemulsion in rats.JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,30,242-249.
MLA	Shi, YB,et al."Pharmacokinetics and tissue distribution of emodin loaded nanoemulsion in rats".JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 30(2015):242-249.