Development, optimization and evaluation of emodin loaded nanoemulsion prepared by ultrasonic emulsification

doi:10.1016/j.jddst.2015.04.003

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	Development, optimization and evaluation of emodin loaded nanoemulsion prepared by ultrasonic emulsification
	Shi, YB; Li, HL; Li, JC; Zhi, DJ; Zhang, XY; Liu, H; Wang, HQ; Li, HY; Shi, YB (reprint author), Lanzhou Univ, Sch Pharm, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.
刊名	JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
	2015-06
卷号	27 页码:46-55
关键词	Emodin Nanoemulsion Response surface methodology Ultrasonic emulsification Releasing mechanism
ISSN号	1773-2247
DOI	10.1016/j.jddst.2015.04.003
文献子类	Article
英文摘要	Emodin loaded nanoemulsion (EMO-NE) was optimized by using response surface methodology (RSM) based on central composite design to investigate the influence of main formulation variables as well as ultrasonic operating parameters on the properties of nanoemulsion. Furthermore, in order to find the best compromise between several responses, the desirability function was optimized the responses successfully. RSM analysis demonstrated that the experimental data can be fitted into a second-order polynomial model and actual values of the formulated nanoemulsion were in a good agreement with predicted values. The optimal formulation was mainly constituted with 11.84% (w/w) capryol 90 containing emodin, 20.16% (w/w) cremophor RH 40/transcutol HP. Ultrasonic operating time was set as 23.42 min and the operating power was set at 156 w. The introducing of oleic acid and pH adjustment can easily improve the zeta potential of EMO-NE. The mean zeta potential of the optimized EMO-NE was -25.2 +/- 0.5 mV and the diameter was in the range of 10-30 nm. About 80.79 +/- 1.11% of emodin was found to be released from EMO-NE in vitro after 120 h, and it was assumed that drug releasing mechanism is following a Fickian diffusion mechanism. (C) 2015 Elsevier B.V. All rights reserved.
学科主题	Pharmacology & Pharmacy
出版地	AMSTERDAM
资助项目	甘肃省自然科学基金计划
项目编号	Natural Science Grant of Gansu [145RJZA026] ; Agricultural Biotechnology Research and Development Project of Gansu, PR China [GNSW-2013-14]
语种	英语
WOS记录号	WOS:000355359000006
资助机构	GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179547]
专题	药学院_期刊论文
通讯作者	Shi, YB (reprint author), Lanzhou Univ, Sch Pharm, 199 Donggang West Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Shi, YB,Li, HL,Li, JC,et al. Development, optimization and evaluation of emodin loaded nanoemulsion prepared by ultrasonic emulsification[J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,2015,27:46-55.
APA	Shi, YB.,Li, HL.,Li, JC.,Zhi, DJ.,Zhang, XY.,...&Shi, YB .(2015).Development, optimization and evaluation of emodin loaded nanoemulsion prepared by ultrasonic emulsification.JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,27,46-55.
MLA	Shi, YB,et al."Development, optimization and evaluation of emodin loaded nanoemulsion prepared by ultrasonic emulsification".JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 27(2015):46-55.