Quantification and bio-assay of alpha-glucosidase inhibitors from the roots of Glycyrrhiza uralensis Fisch.

doi:10.1080/14786419.2015.1114940

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	Quantification and bio-assay of alpha-glucosidase inhibitors from the roots of Glycyrrhiza uralensis Fisch.
	Gou, SH; Liu, J; He, M; Qiang, Y; Ni, JM; Ni, JM (reprint author), Lanzhou Univ, Inst Pharmaceut, Sch Pharm, Lanzhou, Peoples R China.
刊名	NATURAL PRODUCT RESEARCH
	2016
卷号	30 期号:18 页码:2130-2134
关键词	Glycyrrhiza uralensis licorice alpha-glucosidase flavonoid hypoglycaemic antidiabetic
ISSN号	1478-6419
DOI	10.1080/14786419.2015.1114940
文献子类	Article
英文摘要	This work aimed to investigate the -glucosidase inhibitor from the roots of Glycyrrhiza uralensis Fisch. Seven flavonoids were isolated, and the total content of compounds 1-7 were more than 50% in Glycyrrhiza total flavones (GTF), and the content of compound 1 and 2 was abundant in GTF. The results of the -glucosidase inhibitory activities indicated that compounds 1-6 and GTF respectively with the IC50 values of 31.303, 30.263, 23.363, 19.528, 10.854, 26.454 and 21.641g/mL exhibited the more potent activity than acarbose with the IC50 values of 38.995g/mL. These result suggested that Glycyrrhiza flavonoids may become a valid alternative of potential basis for new hypoglycaemic and antidiabetic agents. [GRAPHICS] .
学科主题	Chemistry ; Pharmacology & Pharmacy
出版地	ABINGDON
资助项目	国家自然科学基金项目 ; 甘肃省科技支撑计划
项目编号	Science & Technology Pillar program Foundation of Gansu Province [1204FKCA151] ; National Natural Science Foundation of China [81273440]
语种	英语
WOS记录号	WOS:000382576400018
资助机构	NSFC ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179533]
专题	药学院_期刊论文
通讯作者	Ni, JM (reprint author), Lanzhou Univ, Inst Pharmaceut, Sch Pharm, Lanzhou, Peoples R China.
推荐引用方式 GB/T 7714	Gou, SH,Liu, J,He, M,et al. Quantification and bio-assay of alpha-glucosidase inhibitors from the roots of Glycyrrhiza uralensis Fisch.[J]. NATURAL PRODUCT RESEARCH,2016,30(18):2130-2134.
APA	Gou, SH,Liu, J,He, M,Qiang, Y,Ni, JM,&Ni, JM .(2016).Quantification and bio-assay of alpha-glucosidase inhibitors from the roots of Glycyrrhiza uralensis Fisch..NATURAL PRODUCT RESEARCH,30(18),2130-2134.
MLA	Gou, SH,et al."Quantification and bio-assay of alpha-glucosidase inhibitors from the roots of Glycyrrhiza uralensis Fisch.".NATURAL PRODUCT RESEARCH 30.18(2016):2130-2134.