Application of Response Surface Methodology for Optimization of Resveratrol Liquid Crystalline Nanoparticles | |
Li, L; Zhang, XY; Chen, Y; You, JQ; Qiao, H; Liu, JX; Shi, YB; Zhao, XN; Zhang, XY (reprint author), Lanzhou Univ, Coll Pharm, Lanzhou 730000, Gansu, Peoples R China. | |
刊名 | LATIN AMERICAN JOURNAL OF PHARMACY |
2015 | |
卷号 | 34期号:4页码:773-781 |
关键词 | central composite design desirability function liquid crystalline nanoparticles response surface methodology resveratrol |
ISSN号 | 0326-2383 |
文献子类 | Article |
英文摘要 | The objective of this study was to prepare and characterize resveratrol liquid crystalline nanoparticles (RES-LCNPs). Response surface methodology (RSM) was employed to optimize the composition of RES-LCNPs. The optimized RES-LCNPs composition with the ratio of GMO (glyceryl monoolein) to RES concentration of 21.7:1, RES concentration of 0.4 g/L and PVA (polivinil alcohol) concentration of 0.91 g/L provided the desired characteristics. The RES-LCNPs presented nearly sphere structure under transmission electron microscopy (TEM), with an average diameter of 50.77 +/- 5.14 nm and zeta potential of -22.6 +/- 1.9 mV. Differential scanning calorimetry (DSC) analyses revealed that RES was present in the LCNPs. The in vitro release profile of the optimized RES-LCNPs exhibited a biphasic pattern with burst release initially and sustained release afterwards. The results indicated that the optimized LCNPs had the potential to be exploited as RES delivery system for achieving sustained release. |
学科主题 | Pharmacology & Pharmacy |
出版地 | LA PLATA |
语种 | 英语 |
WOS记录号 | WOS:000355286500019 |
内容类型 | 期刊论文 |
源URL | [http://ir.lzu.edu.cn/handle/262010/179519] |
专题 | 药学院_期刊论文 |
通讯作者 | Zhang, XY (reprint author), Lanzhou Univ, Coll Pharm, Lanzhou 730000, Gansu, Peoples R China. |
推荐引用方式 GB/T 7714 | Li, L,Zhang, XY,Chen, Y,et al. Application of Response Surface Methodology for Optimization of Resveratrol Liquid Crystalline Nanoparticles[J]. LATIN AMERICAN JOURNAL OF PHARMACY,2015,34(4):773-781. |
APA | Li, L.,Zhang, XY.,Chen, Y.,You, JQ.,Qiao, H.,...&Zhang, XY .(2015).Application of Response Surface Methodology for Optimization of Resveratrol Liquid Crystalline Nanoparticles.LATIN AMERICAN JOURNAL OF PHARMACY,34(4),773-781. |
MLA | Li, L,et al."Application of Response Surface Methodology for Optimization of Resveratrol Liquid Crystalline Nanoparticles".LATIN AMERICAN JOURNAL OF PHARMACY 34.4(2015):773-781. |
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