In vitro inhibition of rat monoamine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis

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	In vitro inhibition of rat monoamine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis
	Pan, X; Kong, LD; Zhang, Y; Cheng, CHK; Tan, RX
刊名	ACTA PHARMACOLOGICA SINICA
	2000-10
卷号	21 期号:10 页码:949-953
关键词	liquiritigenin isoliquiritigenin Sinofranchetia chinensis Lardizabalaceae monoamine oxidase 甘草素异甘草素串果藤木通科单胺氧化酶
ISSN号	0253-9756
其他题名	串果藤中甘草素和异甘草素对大鼠单胺氧化酶的体外抑制作用(英文)
通讯作者	Tan, RX (reprint author), Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Inst Funct Biomol, Nanjing 210093, Peoples R China.
中文摘要	目的:研究串果藤中甘草素和异甘草素体外对单胺氧化酶A型和B型的抑制作用.方法:根据不同的离心速度制备大鼠全脑粗线粒体作为单胺氧化酶的酶源;分别以5-羟基[侧链-2-~(14)C]色胺肌酸硫酸盐([~(14)C]5-HT)和2-苯基[1-~(14)C]乙基胺盐酸盐([~(14)C]β-PEA)为单胺氧化酶A型和B型放射性底物,用液体闪烁技术,研究甘草素和异甘草素酶抑制作用和抑制类型.结果:甘草素和异甘草素对单胺氧化酶A型和B型均具有抑制作用,呈良好的量效关系,对单胺氧化酶A型的IC_(50)(95％的可信限)分别为32(26-36)μmol/L和13.9(12.8-15.6)μmol/L,对单胺...
学科主题	Chemistry; Pharmacology & Pharmacy
收录类别	SCIE ; PUBMED ; MEDLINE ; CSCD
出版地	SHANGHAI
语种	英语
WOS记录号	WOS:000089725800017
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121840]
专题	药学院_期刊论文
推荐引用方式 GB/T 7714	Pan, X,Kong, LD,Zhang, Y,et al. In vitro inhibition of rat monoamine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis[J]. ACTA PHARMACOLOGICA SINICA,2000,21(10):949-953.
APA	Pan, X,Kong, LD,Zhang, Y,Cheng, CHK,&Tan, RX.(2000).In vitro inhibition of rat monoamine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis.ACTA PHARMACOLOGICA SINICA,21(10),949-953.
MLA	Pan, X,et al."In vitro inhibition of rat monoamine oxidase by liquiritigenin and isoliquiritigenin isolated from Sinofranchetia chinensis".ACTA PHARMACOLOGICA SINICA 21.10(2000):949-953.