Ampelopsin sodium induces mitochondrial-mediated apoptosis in human lung adenocarcinoma SPC-A-1 cell line

doi:10.1691/ph.2016.6571

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	Ampelopsin sodium induces mitochondrial-mediated apoptosis in human lung adenocarcinoma SPC-A-1 cell line
	Jiang, JF; Zhai, J; Liu, ZRJ; Chao, L; Zhao, YF; Wu, YJ; Cui, MX; Cui, MX (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drug Gansu Prov, Inst Pharmacol, Sch Basic Med Sci, Lanzhou, Peoples R China.; Cui, MX (reprint author), Lanzhou Univ, Sch Basic Med Sci, Dept Pharmacol, 199 Dongang Xi Rd, Lanzhou 730000, Peoples R China.
刊名	PHARMAZIE
	2016-08
卷号	71 期号:8 页码:455-459
ISSN号	0031-7144
DOI	10.1691/ph.2016.6571
文献子类	Article
英文摘要	Ampelopsin is a well-known flavonoid which has variety of biological and pharmacological actions including anticancer effects and induction of apoptosis on the several cancer cell lines. The present study aimed to evaluate the role of ampelopsin sodium (Amp-Na) in the mitochondrial-mediated apoptosis of human lung adenocarcionma SPC-A-1 cells. The analysis of cell proliferation and ultrastructure were performed. Furthermore, to clarify its action mechanism by determining the mitochondrial membrane potential (Delta psi m), intracellular calcium (Ca2+) concentration, mitochondrial nitric oxide (NO) level and total ATPase activity. The results showed that Amp-Na markedly inhibited the SPC-A-1 cell proliferation and caused ultrastructural apoptosis feature in SPC-A-1 cells in a dose-dependent manner. Amp-Na led to a rapid and sustained Ca2+ elevation and Delta psi m reduction, and induced the mitochondrial NO production and decreased the total ATPase activity in SPC-A-1 cells. The results enhance the potential of Amp-Na as a therapeutic drug for treating lung cancer, and provide new information for mechanism of Amp-Na which induces mitochondrial-mediated apoptosis in tumor cells.
学科主题	Pharmacology & Pharmacy ; Chemistry
出版地	ESCHBORN
项目编号	Guangdong Science and Technology Department of the provincial Ministry of Industry- University-Research cooperation projects [2007A090302025]
语种	英语
WOS记录号	WOS:000385261200005
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/188737]
专题	基础医学院_期刊论文
通讯作者	Wu, YJ; Cui, MX (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drug Gansu Prov, Inst Pharmacol, Sch Basic Med Sci, Lanzhou, Peoples R China.; Cui, MX (reprint author), Lanzhou Univ, Sch Basic Med Sci, Dept Pharmacol, 199 Dongang Xi Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Jiang, JF,Zhai, J,Liu, ZRJ,et al. Ampelopsin sodium induces mitochondrial-mediated apoptosis in human lung adenocarcinoma SPC-A-1 cell line[J]. PHARMAZIE,2016,71(8):455-459.
APA	Jiang, JF.,Zhai, J.,Liu, ZRJ.,Chao, L.,Zhao, YF.,...&Cui, MX .(2016).Ampelopsin sodium induces mitochondrial-mediated apoptosis in human lung adenocarcinoma SPC-A-1 cell line.PHARMAZIE,71(8),455-459.
MLA	Jiang, JF,et al."Ampelopsin sodium induces mitochondrial-mediated apoptosis in human lung adenocarcinoma SPC-A-1 cell line".PHARMAZIE 71.8(2016):455-459.