Ampelopsin sodium induces mitochondrial-mediated apoptosis in human lung adenocarcinoma SPC-A-1 cell line | |
Jiang, JF; Zhai, J; Liu, ZRJ; Chao, L; Zhao, YF; Wu, YJ; Cui, MX; Cui, MX (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drug Gansu Prov, Inst Pharmacol, Sch Basic Med Sci, Lanzhou, Peoples R China.; Cui, MX (reprint author), Lanzhou Univ, Sch Basic Med Sci, Dept Pharmacol, 199 Dongang Xi Rd, Lanzhou 730000, Peoples R China. | |
刊名 | PHARMAZIE
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2016-08 | |
卷号 | 71期号:8页码:455-459 |
ISSN号 | 0031-7144 |
DOI | 10.1691/ph.2016.6571 |
文献子类 | Article |
英文摘要 | Ampelopsin is a well-known flavonoid which has variety of biological and pharmacological actions including anticancer effects and induction of apoptosis on the several cancer cell lines. The present study aimed to evaluate the role of ampelopsin sodium (Amp-Na) in the mitochondrial-mediated apoptosis of human lung adenocarcionma SPC-A-1 cells. The analysis of cell proliferation and ultrastructure were performed. Furthermore, to clarify its action mechanism by determining the mitochondrial membrane potential (Delta psi m), intracellular calcium (Ca2+) concentration, mitochondrial nitric oxide (NO) level and total ATPase activity. The results showed that Amp-Na markedly inhibited the SPC-A-1 cell proliferation and caused ultrastructural apoptosis feature in SPC-A-1 cells in a dose-dependent manner. Amp-Na led to a rapid and sustained Ca2+ elevation and Delta psi m reduction, and induced the mitochondrial NO production and decreased the total ATPase activity in SPC-A-1 cells. The results enhance the potential of Amp-Na as a therapeutic drug for treating lung cancer, and provide new information for mechanism of Amp-Na which induces mitochondrial-mediated apoptosis in tumor cells. |
学科主题 | Pharmacology & Pharmacy ; Chemistry |
出版地 | ESCHBORN |
项目编号 | Guangdong Science and Technology Department of the provincial Ministry of Industry- University-Research cooperation projects [2007A090302025] |
语种 | 英语 |
WOS记录号 | WOS:000385261200005 |
内容类型 | 期刊论文 |
源URL | [http://ir.lzu.edu.cn/handle/262010/188737] ![]() |
专题 | 基础医学院_期刊论文 |
通讯作者 | Wu, YJ; Cui, MX (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drug Gansu Prov, Inst Pharmacol, Sch Basic Med Sci, Lanzhou, Peoples R China.; Cui, MX (reprint author), Lanzhou Univ, Sch Basic Med Sci, Dept Pharmacol, 199 Dongang Xi Rd, Lanzhou 730000, Peoples R China. |
推荐引用方式 GB/T 7714 | Jiang, JF,Zhai, J,Liu, ZRJ,et al. Ampelopsin sodium induces mitochondrial-mediated apoptosis in human lung adenocarcinoma SPC-A-1 cell line[J]. PHARMAZIE,2016,71(8):455-459. |
APA | Jiang, JF.,Zhai, J.,Liu, ZRJ.,Chao, L.,Zhao, YF.,...&Cui, MX .(2016).Ampelopsin sodium induces mitochondrial-mediated apoptosis in human lung adenocarcinoma SPC-A-1 cell line.PHARMAZIE,71(8),455-459. |
MLA | Jiang, JF,et al."Ampelopsin sodium induces mitochondrial-mediated apoptosis in human lung adenocarcinoma SPC-A-1 cell line".PHARMAZIE 71.8(2016):455-459. |
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