Salusin beta Within the Nucleus Tractus Solitarii Suppresses Blood Pressure Via Inhibiting the Activities of Presympathetic Neurons in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats

doi:10.1007/s12012-015-9330-2

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	Salusin beta Within the Nucleus Tractus Solitarii Suppresses Blood Pressure Via Inhibiting the Activities of Presympathetic Neurons in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats
	Li, HB; Lu, Y; Liu, JJ; Miao, YW; Zheng, TZ; Su, Q; Qi, J; Tan, H; Yuan, ZY; Zhu, GQ
刊名	CARDIOVASCULAR TOXICOLOGY
	2016-07
卷号	16 期号:3 页码:223-234
关键词	Salusin Nucleus tractus solitarii Rostral ventrolateral medulla Baroreflex Presympathetic neuron
ISSN号	1530-7905
DOI	10.1007/s12012-015-9330-2
文献子类	Article
英文摘要	Salusin beta is a newly identified bioactive peptide, which shows peripheral hypotensive, mitogenic and proatherosclerotic effects. The present study was undertaken to investigate the role of salusin beta within the nucleus tractus solitarii (NTS) and the underlying mechanism in regulating blood pressure and heart rate (HR) in spontaneously hypertensive rats (SHR). Our results showed that bilateral or unilateral microinjection of salusin beta (0.4-40 pmol) into the NTS in SHR decreased mean arterial pressure and HR in a dose-dependent manner. Bilateral microinjection of salusin beta (4 pmol) within NTS improved baroreflex sensitivity functions in SHR. Pretreatment with glutamate receptors antagonist kynurenic acid (5 nmol) into the NTS in SHR did not alter the salusin beta (4 pmol) induced hypotension and bradycardia. Likewise, bilateral vagotomy also did not alter the salusin beta (4 pmol) induced hypotension and bradycardia. However, pretreatment with GABA(A) receptors agonist muscimol (100 pmol) within the rostral ventrolateral medulla (RVLM) in SHR almost completely abolished the hypotension and bradycardia evoked by intra-NTS salusin beta (4 pmol). Our findings suggested that microinjection of salusin beta into the NTS produced hypotension and bradycardia, as well as improved baroreflex sensitivity functions, via inhibiting the activities of presympathetic neurons in the RVLM in SHR.
学科主题	Cardiovascular System & Cardiology ; Toxicology
出版地	TOTOWA
资助项目	国家自然科学基金项目 ; 国家重点基础研究发展计划以及国家重大科学研究计划（973计划）
项目编号	National Basic Research Program of China [2012CB517805] ; National Natural Science Foundation of China [30700266, 91439120, 81170248, 31171095, 81370356]
语种	英语
WOS记录号	WOS:000377795400003
资助机构	NSFC ; MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179128]
专题	基础医学院_期刊论文
通讯作者	Kang, YM (reprint author), Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Xian 710061, Peoples R China.; Lu, Y (reprint author), SanAiTang Hosp, Dept Clin Lab, Lanzhou 730030, Peoples R China.
推荐引用方式 GB/T 7714	Li, HB,Lu, Y,Liu, JJ,et al. Salusin beta Within the Nucleus Tractus Solitarii Suppresses Blood Pressure Via Inhibiting the Activities of Presympathetic Neurons in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats[J]. CARDIOVASCULAR TOXICOLOGY,2016,16(3):223-234.
APA	Li, HB.,Lu, Y.,Liu, JJ.,Miao, YW.,Zheng, TZ.,...&Lu, Y .(2016).Salusin beta Within the Nucleus Tractus Solitarii Suppresses Blood Pressure Via Inhibiting the Activities of Presympathetic Neurons in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats.CARDIOVASCULAR TOXICOLOGY,16(3),223-234.
MLA	Li, HB,et al."Salusin beta Within the Nucleus Tractus Solitarii Suppresses Blood Pressure Via Inhibiting the Activities of Presympathetic Neurons in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats".CARDIOVASCULAR TOXICOLOGY 16.3(2016):223-234.