Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model

doi:10.1016/j.neuropharm.2015.12.014

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	Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model
	Parmentier, R; Zhao, Y; Perier, M; Akaoka, H; Lintunen, M; Hou, YP; Panula, P; Watanabe, T; Franco, P; Lin, JS
刊名	NEUROPHARMACOLOGY
	2016-07
卷号	106 页码:20-34
关键词	Wakefulness Arousal Sleep Cortical activation Histamine H1-receptor Knockout mice EEG Behavior Cholinergic transmission Compensation
ISSN号	0028-3908
DOI	10.1016/j.neuropharm.2015.12.014
文献子类	Article
英文摘要	Using knockout (KO) mice lacking the histamine (HA)-synthesizing enzyme (histidine decarboxylase, HDC), we have previously shown the importance of histaminergic neurons in maintaining wakefulness (W) under behavioral challenges. Since the central actions of HA are mediated by several receptor subtypes, it remains to be determined which one(s) could be responsible for such a role. We have therefore compared the cortical-EEG, sleep and W under baseline conditions or behavioral/pharmacological stimuli in littermate wild-type (WT) and H1-receptor KO (H1-/-) mice. We found that H1-/- mice shared several characteristics with HDC KO mice, i.e. 1) a decrease in W after lights-off despite its normal baseline daily amount; 2) a decreased EEG slow wave sleep (SWS)/W power ratio; 3) inability to maintain W in response to behavioral challenges demonstrated by a decreased sleep latency when facing various stimuli. These effects were mediated by central H1-receptors. Indeed, in WT mice, injection of triprolidine, a brain-penetrating H1-receptor antagonist increased SWS, whereas ciproxifan (H3-receptor antagonist/inverse agonist) elicited W; all these injections had no effect in H1-/- mice. Finally, H1-/- mice showed markedly greater changes in EEG power (notably in the 0.8-5 Hz band) and sleep-wake cycle than in WT mice after application of a cholinergic antagonist or an indirect agonist, i.e., scopolamine or physostigmine. Hence, the role of HA in wake-promotion is largely ensured by H1-receptors. An upregulated cholinergic system may account for a quasi-normal daily amount of W in HDC or H1-receptor KO mice and likely constitutes a major compensatory mechanism when the brain is facing deficiency of an activating system. This article is part of the Special Issue entitled 'Histamine Receptors'. Copyright (C) 2015 Elsevier Ltd. All rights reserved.
学科主题	Neurosciences & Neurology ; Pharmacology & Pharmacy
出版地	OXFORD
项目编号	INSERM, Claude Bernard University ; European Contract [QLRT-2001-00826] ; Ministere de l'education nationale, de la recherche et de la technologie (France) ; Institut Franco-Chinois (Lyon, France)
语种	英语
WOS记录号	WOS:000378964500004
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179127]
专题	基础医学院_期刊论文
通讯作者	Lin, JS (reprint author), Univ Lyon 1, CNRS UMR5292, INSERM U1028,Waking Team, CRNL,Integrat Physiol Brain Arousal Syst,Sch Med, 8 Av Rockefeller, F-69373 Lyon, France.
推荐引用方式 GB/T 7714	Parmentier, R,Zhao, Y,Perier, M,et al. Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model[J]. NEUROPHARMACOLOGY,2016,106:20-34.
APA	Parmentier, R.,Zhao, Y.,Perier, M.,Akaoka, H.,Lintunen, M.,...&Lin, JS .(2016).Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model.NEUROPHARMACOLOGY,106,20-34.
MLA	Parmentier, R,et al."Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model".NEUROPHARMACOLOGY 106(2016):20-34.