Application of a C-C Bond-Forming Conjugate Addition Reaction in Asymmetric Dearomatization of beta-Naphthols

doi:10.1002/anie.201503056

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	Application of a C-C Bond-Forming Conjugate Addition Reaction in Asymmetric Dearomatization of beta-Naphthols
	Yang, DX; Wang, LQ; Kai, M; Li, D; Yao, XJ; Wang, R; Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2015-08-10
卷号	54 期号:33 页码:9523-9527
关键词	arenes aromaticity DFT calculations magnesium naphthols
ISSN号	1433-7851
DOI	10.1002/anie.201503056
其他题名	Application of a C-C Bond-Forming Conjugate Addition Reaction in Asymmetric Dearomatization of β-Naphthols
文献子类	Article
英文摘要	A CC bond-forming conjugate reaction was successfully applied to the enantioselective dearomatization of -naphthols. A C(sp2)C(sp3) bond is formed by using propargylic ketones as reactive partners. Good to excellent Z/Eratios and eevalues were obtained by employing an insitu generated magnesium catalyst. Further transformations of the Z-configured CC double bond in the products were achieved under mild reaction conditions. Moreover, the stereocontrolling element of this magnesium-catalyzed dearomatization reaction was explored by computational chemistry.
学科主题	Chemistry
出版地	WEINHEIM
资助项目	国家自然科学基金项目 ; 国家科技重大专项 ; 长江学者和创新团队发展计划
项目编号	NSFC [21432003, 81473095, 91213302, 91413107] ; National S&T Major Project of China [2012ZX09504001-003] ; Changjiang Scholars and Innovative Research Team in University [IRT1137]
语种	英语
WOS记录号	WOS:000358987300010
资助机构	NSFC ; MOST ; MOE
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/179055]
专题	基础医学院_期刊论文
通讯作者	Wang, R (reprint author), Lanzhou Univ, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Yang, DX,Wang, LQ,Kai, M,et al. Application of a C-C Bond-Forming Conjugate Addition Reaction in Asymmetric Dearomatization of beta-Naphthols[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2015,54(33):9523-9527.
APA	Yang, DX.,Wang, LQ.,Kai, M.,Li, D.,Yao, XJ.,...&Wang, R .(2015).Application of a C-C Bond-Forming Conjugate Addition Reaction in Asymmetric Dearomatization of beta-Naphthols.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,54(33),9523-9527.
MLA	Yang, DX,et al."Application of a C-C Bond-Forming Conjugate Addition Reaction in Asymmetric Dearomatization of beta-Naphthols".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 54.33(2015):9523-9527.