Rhodium-Catalyzed Asymmetric Hydrogenation of Unprotected NH Imines Assisted by a Thiourea

doi:10.1002/anie.201404570

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	Rhodium-Catalyzed Asymmetric Hydrogenation of Unprotected NH Imines Assisted by a Thiourea
	Zhao, QY; Wen, JL; Tan, RC; Huang, KX; Metola, P; Wang, R; Anslyn, EV; Zhang, XM; Wang, R (reprint author), Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2014-08-04
卷号	53 期号:32 页码:8467-8470
关键词	asymmetric catalysis hydrogenation ion pairs reaction mechanisms rhodium
ISSN号	1521-3773
DOI	10.1002/anie.201404570
文献子类	Article
英文摘要	2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Asymmetric hydrogenation of unprotected NH imines catalyzed by rhodium/bis(phosphine)-thiourea provided chiral amines with up to 97% yield and 95% ee. (1)H NMR studies, coupled with control experiments, implied that catalytic chloride-bound intermediates were involved in the mechanism through a dual hydrogen-bonding interaction. Deuteration experiments proved that the hydrogenation proceeded through a pathway consistent with an imine.
学科主题	Chemistry
出版地	WEINHEIM
资助项目	国家自然科学基金项目 ; 国家科技重大专项 ; 国家留学基金委项目 ; 美国国家科学基金项目 ; 美国国立卫生研究院项目
项目编号	National Science Foundation [NSF CHE 0956784] ; China Scholarship Council ; National S&T Major Project of China [2012ZX09504001-003] ; National Institutes of Health [NIH R01 GM077437]
语种	英语
WOS记录号	WOS:000340522700038
资助机构	NSFC ; MOST ; CSC ; US NSF ; NIH
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/163958]
专题	基础医学院_期刊论文
通讯作者	Wang, R (reprint author), Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Zhao, QY,Wen, JL,Tan, RC,et al. Rhodium-Catalyzed Asymmetric Hydrogenation of Unprotected NH Imines Assisted by a Thiourea[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2014,53(32):8467-8470.
APA	Zhao, QY.,Wen, JL.,Tan, RC.,Huang, KX.,Metola, P.,...&Wang, R .(2014).Rhodium-Catalyzed Asymmetric Hydrogenation of Unprotected NH Imines Assisted by a Thiourea.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,53(32),8467-8470.
MLA	Zhao, QY,et al."Rhodium-Catalyzed Asymmetric Hydrogenation of Unprotected NH Imines Assisted by a Thiourea".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53.32(2014):8467-8470.