Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis

doi:10.7314/APJCP.2014.15.15.6103

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	Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis
	Zeng, R; Duan, L; Kong, YK; Wu, XL; Wang, Y; Xin, G; Yang, KH; Yang, KH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Peoples R China.
刊名	ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
	2014-08-18
卷号	15 期号:15 页码:6103-6108
关键词	beta-catenin esophageal carcinoma prognosis meta-analysis
ISSN号	1513-7368
DOI	10.7314/APJCP.2014.15.15.6103
文献子类	Article
英文摘要	Many studies have reported beta-catenin involvement in the development of esophageal carcinoma (EC), but its prognostic significance for EC patients remains controversial. Therefore, we conducted this meta-analysis to explore the issue in detail. After searching PubMed, EMBASE, Web of Science, and Chinese Biomedical Literature Database, we included a total of ten relevant studies. We pooled the overall survival (OS) data using RevMan 5.2 software. The results showed that aberrant expression of beta-catenin was associated with a significant increase of mortality risk (hazard ratio 1.71, 95% CI 1.46-2.01; p<0.00001). Subgroup analyses further suggested that aberrant expression of beta-catenin resulted in poor OS of EC patients regardless of histological type of EC, study location or criteria for aberrant expression of beta-catenin, and the sensitivity analyses revealed that the result was robust. The meta-analysis revealed that aberrant expression of beta-catenin could be a predicative factor of poor prognosis for EC patients.
学科主题	Oncology
出版地	GYEONGGI-DO
语种	英语
WOS记录号	WOS:000343723600024
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121734]
专题	基础医学院_期刊论文
通讯作者	Yang, KH (reprint author), Lanzhou Univ, Evidence Based Med Ctr, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Zeng, R,Duan, L,Kong, YK,et al. Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(15):6103-6108.
APA	Zeng, R.,Duan, L.,Kong, YK.,Wu, XL.,Wang, Y.,...&Yang, KH .(2014).Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis.ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,15(15),6103-6108.
MLA	Zeng, R,et al."Prognostic Significance of Beta-Catenin Expression in Patients with Esophageal Carcinoma: a Meta-analysis".ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 15.15(2014):6103-6108.