Isocorydine Derivatives and Their Anticancer Activities

doi:10.3390/molecules190812099

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	Isocorydine Derivatives and Their Anticancer Activities
	Zhong, M; Liu, YJ; Liu, JX; Di, DL; Xu, MR; Yang, YY; Li, WG; Chen, YL; Liu, JX; Liu, JX (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China.
刊名	MOLECULES
	2014-08
卷号	19 期号:8 页码:12099-12115
关键词	aporphine alkaloids isocorydine synthesis anticancer activity
ISSN号	1420-3049
DOI	10.3390/molecules190812099
文献子类	Article
英文摘要	In order to improve the anticancer activity of isocorydine (ICD), ten isocorydine derivatives were prepared through chemical structure modifications, and their in vitro and in vivo activities were experimentally investigated. 8-Amino-isocorydine (8) and 6a, 7-dihydrogen-isocorydione (10) could inhibit the growth of human lung (A549), gastric (SGC7901) and liver (HepG2) cancer cell lines in vitro. Isocorydione (2) could inhibit the tumor growth of murine sarcoma S-180-bearing mice, and 8-acetamino-isocorydine (11), a pro-drug of 8-amino-isocorydine (8), which is instable in water solution at room temperature, had a good inhibitory effect on murine hepatoma H-22-induced tumors. The results suggested that the isocorydine structural modifications at C-8 could significantly improve the biological activity of this alkaloid, indicating its suitability as a lead compound in the development of an effective anticancer agent.
学科主题	Chemistry
出版地	BASEL
资助项目	甘肃省科技支撑计划
项目编号	West Light Program ; "Build coalitions of the national academy of sciences" of Chinese Academy of Sciences ; science and technology program of Gansu [1304FKCA062]
语种	英语
WOS记录号	WOS:000341502600079
资助机构	GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121723]
专题	基础医学院_期刊论文
通讯作者	Liu, JX (reprint author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Zhong, M,Liu, YJ,Liu, JX,et al. Isocorydine Derivatives and Their Anticancer Activities[J]. MOLECULES,2014,19(8):12099-12115.
APA	Zhong, M.,Liu, YJ.,Liu, JX.,Di, DL.,Xu, MR.,...&Liu, JX .(2014).Isocorydine Derivatives and Their Anticancer Activities.MOLECULES,19(8),12099-12115.
MLA	Zhong, M,et al."Isocorydine Derivatives and Their Anticancer Activities".MOLECULES 19.8(2014):12099-12115.