Opposite Effects of Neuropeptide FF on Central Antinociception Induced by Endomorphin-1 and Endomorphin-2 in Mice

doi:10.1371/journal.pone.0103773

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	Opposite Effects of Neuropeptide FF on Central Antinociception Induced by Endomorphin-1 and Endomorphin-2 in Mice
	Wang, ZL; Fang, Q; Han, ZL; Pan, JX; Li, XH; Li, N; Tang, HH; Wang, P; Zheng, T; Chang, XM
刊名	PLOS ONE
	2014-08-04
卷号	9 期号:8 页码:-
ISSN号	1932-6203
DOI	10.1371/journal.pone.0103773
文献子类	Article
英文摘要	Neuropeptide FF (NPFF) is known to be an endogenous opioid-modulating peptide. Nevertheless, very few researches focused on the interaction between NPFF and endogenous opioid peptides. In the present study, we have investigated the effects of NPFF system on the supraspinal antinociceptive effects induced by the endogenous m-opioid receptor agonists, endomorphin-1 (EM-1) and endomorphin-2 (EM-2). In the mouse tail-flick assay, intracerebroventricular injection of EM-1 induced antinociception via mu-opioid receptor while the antinociception of intracerebroventricular injected EM-2 was mediated by both mu- and kappa-opioid receptors. In addition, central administration of NPFF significantly reduced EM-1-induced central antinociception, but enhanced EM-2-induced central antinociception. The results using the selective NPFF1 and NPFF2 receptor agonists indicated that the EM-1-modulating action of NPFF was mainly mediated by NPFF2 receptor, while NPFF potentiated EM-2-induecd antinociception via both NPFF1 and NPFF2 receptors. To further investigate the roles of mu- and kappa-opioid systems in the opposite effects of NPFF on central antinociception of endomprphins, the mu- and kappa-opioid receptors selective agonists DAMGO and U69593, respectively, were used. Our results showed that NPFF could reduce the central antinociception of DAMGO via NPFF2 receptor and enhance the central antinociception of U69593 via both NPFF1 and NPFF2 receptors. Taken together, our data demonstrate that NPFF exerts opposite effects on central antinociception of endomorphins and provide the first evidence that NPFF potentiate antinociception of EM-2, which might result from the interaction between NPFF and kappa-opioid systems.
学科主题	Science & Technology - Other Topics
出版地	SAN FRANCISCO
资助项目	国家自然科学基金项目 ; 国家科技重大专项 ; 新世纪优秀人才支持计划 ; 长江学者和创新团队发展计划
项目编号	National Natural Science Foundation of China [81273355] ; Key National S&T Program of the Ministry of Science and Technology [2012ZX09504001-003] ; Program for Changjiang Scholars and Innovative Research Team in University [IRT1137] ; Program for New Century Excellent Talents in University [NCET-13-0257]
语种	英语
WOS记录号	WOS:000339812700053
资助机构	NSFC ; MOST ; MOE
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121713]
专题	基础医学院_期刊论文
通讯作者	Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Wang, ZL,Fang, Q,Han, ZL,et al. Opposite Effects of Neuropeptide FF on Central Antinociception Induced by Endomorphin-1 and Endomorphin-2 in Mice[J]. PLOS ONE,2014,9(8):-.
APA	Wang, ZL.,Fang, Q.,Han, ZL.,Pan, JX.,Li, XH.,...&Wang, R .(2014).Opposite Effects of Neuropeptide FF on Central Antinociception Induced by Endomorphin-1 and Endomorphin-2 in Mice.PLOS ONE,9(8),-.
MLA	Wang, ZL,et al."Opposite Effects of Neuropeptide FF on Central Antinociception Induced by Endomorphin-1 and Endomorphin-2 in Mice".PLOS ONE 9.8(2014):-.