Neuropeptide FF receptor antagonist, RF9, attenuates the fever induced by central injection of LPS in mice

doi:10.1016/j.peptides.2010.12.001

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	Neuropeptide FF receptor antagonist, RF9, attenuates the fever induced by central injection of LPS in mice
	Wang, YQ; Wang, SB; Ma, JL; Guo, J; Fang, Q; Sun, T; Zhuanga, Y; Wang, R; Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tian Shui S Rd, Lanzhou 730000, Peoples R China.
刊名	PEPTIDES
	2011-04
卷号	32 期号:4 页码:702-706
关键词	Neuropeptide FF (NPFF) RF9 Lipopolysaccharide (LPS) Neuroinflammation Fever Mice
ISSN号	0196-9781
DOI	10.1016/j.peptides.2010.12.001
文献子类	Article
英文摘要	The endogenous opioid system has been found to be involved in the fever caused by lipopolysaccharide (LPS). Neuropeptide FF (NPFF, FLFQPQRF-NH2) is an endogenous peptide known to modulate opioid activity, mainly in the central nervous system. Therefore, those data suggested a link between LPS-induced fever and NPFF systems. Using a model of acute neuroinflammation, we sought to determine the effects of NPFF systems on the fever induced by i.c.v. injection of LPS. Coinjected with different doses of NPFF (10 and 30 nmol), the fever of LPS (125 ng) was not modified. Interestingly, the selective NPFF receptors antagonist RF9 (30 nmol) injected into the third ventricle failed to induce significant effect, but it decreased the fever of LPS (125 ng) after cerebral administration in mice. These results suggest that NPFF receptors activation is required for LPS to produce fever. This interaction is the first evidence that NPFF systems participate in the control of acute neuroinflammation in conscious animals. (C) 2011 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
出版地	NEW YORK
资助项目	国家自然科学基金项目 ; 国家科技重大专项
项目编号	National Natural Science Foundation of China [90813012, 20932003] ; Ministry of Science and Technology of China [2009ZX09503-017]
语种	英语
WOS记录号	WOS:000289707300011
资助机构	NSFC ; MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121484]
专题	基础医学院_期刊论文
通讯作者	Wang, R (reprint author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 222 Tian Shui S Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Wang, YQ,Wang, SB,Ma, JL,et al. Neuropeptide FF receptor antagonist, RF9, attenuates the fever induced by central injection of LPS in mice[J]. PEPTIDES,2011,32(4):702-706.
APA	Wang, YQ.,Wang, SB.,Ma, JL.,Guo, J.,Fang, Q.,...&Wang, R .(2011).Neuropeptide FF receptor antagonist, RF9, attenuates the fever induced by central injection of LPS in mice.PEPTIDES,32(4),702-706.
MLA	Wang, YQ,et al."Neuropeptide FF receptor antagonist, RF9, attenuates the fever induced by central injection of LPS in mice".PEPTIDES 32.4(2011):702-706.