GABARAP is Overexpressed in Colorectal Carcinoma and Correlates with Shortened Patient Survival

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	GABARAP is Overexpressed in Colorectal Carcinoma and Correlates with Shortened Patient Survival
	Miao, YF; Zhang, YW; Chen, YL; Chen, LB; Wang, FY; Wang, FY (reprint author), Nanjing Univ, Sch Med, Jinling Hosp, Dept Med Oncol, Nanjing 210002, Peoples R China.
刊名	HEPATO-GASTROENTEROLOGY
	2010-03
卷号	57 期号:98 页码:257-261
关键词	gamma-aminobutyric acid type A (GABAA) receptor-associated protein Autophagy Colorectal cancer
ISSN号	0172-6390
文献子类	Article
英文摘要	Background/Aims: gamma-aminobutyric acid type A (GABAA) receptor associated protein (GABARAP), the mammalian homologue of yeast Atg8, is involved in autophagosome formation during autophagy. The aim of this study is to explore the expression and its prognostic significance in comparison with various clinicopathological predictors of survival. Methodology: GABARAP protein expression was determined by immunohistochemistry in 103 colorectal cancers. Cytoplasmic immunoreactivity was scored semiquantitatively. The results were analyzed in correlation with various clinicopathological variables, including patient survival. Chi-square test and Kaplan-Meier survival analysis were applied. Results: The expression of GABARAP was significantly higher in colorectal cancers than that in adjacent matched nontumor tissues (51.5% vs 33.0%, p<0.01). Increased expression of GABARAP expression in colorectal cancers was significantly correlated with a low grade of differentiation and shortened overall survival (p<0.05). There were no significant differences between the expression of GABARAP and age, gender, stage, tumor size, location of primary tumor, and lymph node invasion. Conclusions: Our data demonstrated that GABARAP is frequently expressed in colorectal cancer. Overexpression of GABARAP is a new independent prognostic marker, which is associated with poor differentiation as well as shortened overall survival.
学科主题	Gastroenterology & Hepatology ; Surgery
出版地	ATHENS
项目编号	Nanjing Military Command [07M076]
语种	英语
WOS记录号	WOS:000278938200015
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121450]
专题	基础医学院_期刊论文
通讯作者	Wang, FY (reprint author), Nanjing Univ, Sch Med, Jinling Hosp, Dept Med Oncol, Nanjing 210002, Peoples R China.
推荐引用方式 GB/T 7714	Miao, YF,Zhang, YW,Chen, YL,et al. GABARAP is Overexpressed in Colorectal Carcinoma and Correlates with Shortened Patient Survival[J]. HEPATO-GASTROENTEROLOGY,2010,57(98):257-261.
APA	Miao, YF,Zhang, YW,Chen, YL,Chen, LB,Wang, FY,&Wang, FY .(2010).GABARAP is Overexpressed in Colorectal Carcinoma and Correlates with Shortened Patient Survival.HEPATO-GASTROENTEROLOGY,57(98),257-261.
MLA	Miao, YF,et al."GABARAP is Overexpressed in Colorectal Carcinoma and Correlates with Shortened Patient Survival".HEPATO-GASTROENTEROLOGY 57.98(2010):257-261.