Therapeutic effects of a recombinant mutant of the human ciliary neurotrophic factor in a mouse model of metabolic syndrome

doi:10.1691/ph.2010.9713

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	Therapeutic effects of a recombinant mutant of the human ciliary neurotrophic factor in a mouse model of metabolic syndrome
	Cui, MX; Jiang, JF; Zheng, RL; Li, RL; Wang, L; Li, WG; Gao, MT; Yang, LN; Dou, JY; Wu, YJ
刊名	PHARMAZIE
	2010-04
卷号	65 期号:4 页码:279-283
ISSN号	0031-7144
DOI	10.1691/ph.2010.9713
文献子类	Article
英文摘要	Metabolic syndrome (MS) is highly prevalent in developed countries and becoming a serious worldwide public health issue. In this study, we established a MS model by feeding male C57BL/6J mice with a high-fat diet (10%) for 18.5 weeks, studied the therapeutic effects of a recombinant mutant of the human ciliary neurotrophic factor (rhmCNTF) 0.1 (C-0.1) or 0.3 (C-0.3) mg.kg(-1) per day subcutaneously or pair feeding (PF, which mice were restricted to the same amount of food as eaten by C-0.3 treated mice) in MS mice. After 10 days treatment, rhmCNTF reduced obesity related indices, ameliorated glucose and lipid metabolism abnormality, and enhanced insulin sensitivity. In addition, liver function and antioxidant ability of MS mice were improved by rhmCNTF. Pair feeding revealed the same effects as C-0.3 on obesity related indices and insulin sensitivity, but aggravated hepatic steatosis and hepatic function. The results suggest that rhmCNTF could serve as an effective therapeutic agent for MS and related diseases.
学科主题	Pharmacology & Pharmacy ; Chemistry
出版地	ESCHBORN
资助项目	国家自然科学基金项目 ; 甘肃省自然科学基金计划
项目编号	Natural Science Foundation of Gansu Province [3ZS051-A25-091] ; National Natural Science Foundation of China [30600770]
语种	英语
WOS记录号	WOS:000277107500010
资助机构	NSFC ; GSSTD
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121443]
专题	基础医学院_期刊论文
通讯作者	Wu, YJ (reprint author), Lanzhou Univ, Sch Basic Med Sci, Inst Pharmacol, Gansu Prov Key Lab Preclin Study New Drug, 199 Donggang Xi Rd, Lanzhou 730000, Peoples R China.
推荐引用方式 GB/T 7714	Cui, MX,Jiang, JF,Zheng, RL,et al. Therapeutic effects of a recombinant mutant of the human ciliary neurotrophic factor in a mouse model of metabolic syndrome[J]. PHARMAZIE,2010,65(4):279-283.
APA	Cui, MX.,Jiang, JF.,Zheng, RL.,Li, RL.,Wang, L.,...&Wu, YJ .(2010).Therapeutic effects of a recombinant mutant of the human ciliary neurotrophic factor in a mouse model of metabolic syndrome.PHARMAZIE,65(4),279-283.
MLA	Cui, MX,et al."Therapeutic effects of a recombinant mutant of the human ciliary neurotrophic factor in a mouse model of metabolic syndrome".PHARMAZIE 65.4(2010):279-283.