Outbreak of Acute Respiratory Disease in China Caused by B2 Species of Adenovirus Type 11

doi:10.1128/JCM.01769-08

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	Outbreak of Acute Respiratory Disease in China Caused by B2 Species of Adenovirus Type 11
	Zhu, Z; Zhang, Y; Xu, ST; Yu, PB; Tian, XP; Wang, L; Liu, ZH; Tang, LY; Mao, NY; Ji, YX
刊名	JOURNAL OF CLINICAL MICROBIOLOGY
	2009-03
卷号	47 期号:3 页码:697-703
ISSN号	0095-1137
DOI	10.1128/JCM.01769-08
文献子类	Article
英文摘要	An outbreak of acute respiratory tract infection occurred in Shanxi Province, China, from March to April 2006. Of the 254 patients affected by this outbreak, 247 patients were students of a senior high school; 1 of these patients died during the outbreak. Serological tests and blood culture revealed no evidence of bacterial infection. The results of direct reverse transcription-PCR or PCR performed with clinical specimens collected from the patients, including the sole patient who died, were positive for human adenoviruses (HAdVs) but negative for influenza virus, measles virus, rubella virus, mumps virus, parainfluenza virus, respiratory syncytial virus, and human enteroviruses. These findings were confirmed by enzyme-linked immunosorbent assay for HAdV immunoglobulin A, the conventional neutralization test, and viral isolation and identification. Sequencing of the entire hexon gene revealed that HdAV type 11a (HAdV-11a) belonging to the B2 species of HAdV was the etiological agent responsible for the outbreak. However, both the analysis of the phylogenetic relationship and the similarity plot indicated that the sequence of the 3' end of the hexon gene outside the hypervariable regions the HAdV-11a strain isolated in this outbreak may be a recombinant with the sequence of the HAdV-14 strain of species B2. Although isolates of HAdV species B2 seldom cause respiratory infections, they may pose a new global challenge with regard to acute respiratory diseases; this possibility cannot be overlooked and should be carefully considered. Hence, the need to establish and improve both epidemiological and virological surveillance of HAdV infections in China should be emphasized.
学科主题	Microbiology
出版地	WASHINGTON
资助项目	国家高技术研究发展计划（863计划）
项目编号	Ministry of Science and Technology of the People's Republic of China [2007AA02Z463]
语种	英语
WOS记录号	WOS:000263818800026
资助机构	MOST
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121402]
专题	基础医学院_期刊论文
通讯作者	Xu, WB (reprint author), Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, WHO WPRO Reg Reference Measles Lab, 27 Nanwei Rd,Room 505, Beijing 100050, Peoples R China.
推荐引用方式 GB/T 7714	Zhu, Z,Zhang, Y,Xu, ST,et al. Outbreak of Acute Respiratory Disease in China Caused by B2 Species of Adenovirus Type 11[J]. JOURNAL OF CLINICAL MICROBIOLOGY,2009,47(3):697-703.
APA	Zhu, Z.,Zhang, Y.,Xu, ST.,Yu, PB.,Tian, XP.,...&Xu, WB .(2009).Outbreak of Acute Respiratory Disease in China Caused by B2 Species of Adenovirus Type 11.JOURNAL OF CLINICAL MICROBIOLOGY,47(3),697-703.
MLA	Zhu, Z,et al."Outbreak of Acute Respiratory Disease in China Caused by B2 Species of Adenovirus Type 11".JOURNAL OF CLINICAL MICROBIOLOGY 47.3(2009):697-703.