Association of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population

doi:10.1016/j.diabres.2008.06.017

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	Association of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population
	Liu, JX; Liu, J; Li, PQ; Xie, XD; Guo, Q; Tian, LM; Ma, XQ; Zhang, JP; Liu, J; Gao, JY
刊名	DIABETES RESEARCH AND CLINICAL PRACTICE
	2008-10
卷号	82 期号:1 页码:42-47
关键词	Type 2 diabetes Sterol regulatory element-binding protein-1c Polymorphism Lipids Insulin resistance
ISSN号	0168-8227
DOI	10.1016/j.diabres.2008.06.017
文献子类	Article
英文摘要	Aims: The sterol regulatory element-binding protein (SREBP)-1c gene has been identified as a susceptibility gene in metabolic diseases such as type 2 diabetes mellitus (T2DM), obesity, dyslipidemia and insulin resistance. Previous studies suggest that SNP17 (rs2297508, exon18c and G952G) of SREBP-1c gene and a common SREBP-1c SNP6 (rs11868035) are associated with an increased risk of T2DM. The present study aimed to confirm the previously reported association in a Chinese population and to examine the two SREBP-1c SNPs for their associations with insulin resistance and blood lipid. Methods: We genotyped two SREBP-1c SNPs in a case-control study (n = 327) from Chinese, including 156 patients with T2DM and 171 healthy controls, using polymerase chain reaction-denaturing high-performance liquid chromatography (PCR-DHPLC) and tested for association with type 2 diabetes, insulin resistance and blood lipid, respectively. Genotype and allele distributions and haplotype construction were analysed. Results: The genotype and allele distributions of rs2297508 and rs11868035 polymorphisms were significantly different in type 2 diabetic patients compared to controls (P = 0.002 and P = 0.013; 0.00 and 0.001, respectively). Haplotype analyses showed significant association with diabetes risk and confirmed the results of the single SNP analyses. The plasma levels of LDL-c of the minor allele-C carriers of the two SNPs were both significantly higher than the noncarriers in the control group (P < 0.05). Furthermore, insulin resistance index (HOMA-IRI) of the rare homozygotes C/C of rs11868035 was significantly lower than that of T/T in the T2DM group (P < 0.05). Conclusions: These findings indicate that the SREBP-1c SNPs rs2297508 and rs11868035 are associated with a significantly increased risk of T2DM and dyslipidemia in the Chinese population. Moreover, the SNP (rs11868035) is closely related to insulin resistance (IR) in diabetic patients. (C) 2008 Published by Elsevier Ireland Ltd.
学科主题	Endocrinology & Metabolism
出版地	CLARE
资助项目	国家自然科学基金项目 ; 国家科技基础条件平台工作项目 ; 新世纪优秀人才支持计划
项目编号	National Natural Science Foundation of China [30571014] ; Ministry of Science and Technology of PR China [2006DKA21301] ; Ministry of Education of PR China [NCET-05-0885]
语种	英语
WOS记录号	WOS:000260664300005
资助机构	NSFC ; MOST ; MOE
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121392]
专题	基础医学院_期刊论文
通讯作者	Liu, J (reprint author), Peoples Hosp Gansu Prov, Dept Endocrinol, Lanzhou 730000, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Liu, JX,Liu, J,Li, PQ,et al. Association of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population[J]. DIABETES RESEARCH AND CLINICAL PRACTICE,2008,82(1):42-47.
APA	Liu, JX.,Liu, J.,Li, PQ.,Xie, XD.,Guo, Q.,...&Liu, J .(2008).Association of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population.DIABETES RESEARCH AND CLINICAL PRACTICE,82(1),42-47.
MLA	Liu, JX,et al."Association of sterol regulatory element-binding protein-1c gene polymorphism with type 2 diabetes mellitus, insulin resistance and blood lipid levels in Chinese population".DIABETES RESEARCH AND CLINICAL PRACTICE 82.1(2008):42-47.