Ethanolic extracts of Sophora moorcroftiana seeds induce apoptosis of human stomach cancer cell line SGC-7901 in vitro

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	Ethanolic extracts of Sophora moorcroftiana seeds induce apoptosis of human stomach cancer cell line SGC-7901 in vitro
	Ma, XM; Luo, YP; Yu, HJ; Cui, Y; Cui, Y (reprint author), Gansu Agr Univ, Fac Vet Med, Lanzhou 730070, Gansu, Peoples R China.
刊名	AFRICAN JOURNAL OF BIOTECHNOLOGY
	2006-09-18
卷号	5 期号:18 页码:1669-1674
关键词	Sophora moorcroftiana human stomach cancer MTT apoptosis
ISSN号	1684-5315
文献子类	Article
英文摘要	The seeds of Sophora moorcroftiana are used in Chinese traditional medicine for the treatment of verminosis, infectious diseases, and anti-inflammation. To investigate the antitumor and induction of apoptosis activity of Sophora moorcroftiana seeds, the ethanolic extracts from the seeds was prepared and added into the culture of human stomach cancer cell line SGC-7901 in vitro. The proliferation and apoptosis of cells treated with the ethanolic extracts were assessed by tetrazolium salt reduction (MTT) assay, fluorescence microscopy, transmission electron microscopy, flow cytometry and agarose gel electrophoresis of DNA fragmentation. The results showed that the growth of SGC-7901 cells was strongly inhibited by the ethanolic extracts at the concentration ranging between 0.31-5.00 mg/ml, and the apoptosis of treated cells was induced at the concentration of 1.25,2.50, and 5.00 mg/ml in vitro. This suggested that the ethanolic extracts from S. moorcroftiana seeds contain potent antitumor fraction(s) on human stomach cancer SGC-7901 cells.
学科主题	Biotechnology & Applied Microbiology
出版地	NAIROBI
语种	英语
WOS记录号	WOS:000248655600013
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121359]
专题	基础医学院_期刊论文
通讯作者	Cui, Y (reprint author), Gansu Agr Univ, Fac Vet Med, Lanzhou 730070, Gansu, Peoples R China.
推荐引用方式 GB/T 7714	Ma, XM,Luo, YP,Yu, HJ,et al. Ethanolic extracts of Sophora moorcroftiana seeds induce apoptosis of human stomach cancer cell line SGC-7901 in vitro[J]. AFRICAN JOURNAL OF BIOTECHNOLOGY,2006,5(18):1669-1674.
APA	Ma, XM,Luo, YP,Yu, HJ,Cui, Y,&Cui, Y .(2006).Ethanolic extracts of Sophora moorcroftiana seeds induce apoptosis of human stomach cancer cell line SGC-7901 in vitro.AFRICAN JOURNAL OF BIOTECHNOLOGY,5(18),1669-1674.
MLA	Ma, XM,et al."Ethanolic extracts of Sophora moorcroftiana seeds induce apoptosis of human stomach cancer cell line SGC-7901 in vitro".AFRICAN JOURNAL OF BIOTECHNOLOGY 5.18(2006):1669-1674.