Effects of Dangshen on isolated gastric muscle strips in rats

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	Effects of Dangshen on isolated gastric muscle strips in rats
	Zheng, TZ; Li, W; Qu, SY; Ma, YM; Ding, YH; Wei, YL; Zheng, TZ (reprint author), Lanzhou Med Coll, Dept Physiol, Lanzhou 730000, Gansu Province, Peoples R China.
刊名	WORLD JOURNAL OF GASTROENTEROLOGY
	1998-08
卷号	4 期号:4 页码:354-356
关键词	Dangshen stomach muscle, smooth muscle contraction receptors, cholinergic rats
ISSN号	1007-9327
文献子类	Article
英文摘要	AIM To study the effects of Dangshen [dried root of Codonopsis Pilosula (Franch) Nannf] on contractile activity of isolated gastric muscle strips in rats and its possible mechanism involved. METHODS Each isolated gastric muscle strip was put in a tissue chamber containing 5ml Krebs solution, constantly warmed by water jacket at 37 degrees C and supplied with a mixed gas of 95% O-2 and 5% CO2. After incubating for Ih with Ig tension, Dangshen of varied concentration was added cumulatively in the tissue chamber at intervals of 2 minutes. The isometrical response was measured on ink-writing recorders. RESULTS Dangshen dose dependence increased the resting tension of longitudinal muscle (LM) of fundus (r=0.96, P<0.01), the mean contractile amplitude of circular muscle (CM) of the stomach body (r=0.87, P<0.05) and CM of antrum (r=0.98, P<0.01), and the motility index CM of pylorus (r=0.87, P<0.05). Atropine (5 x 10(-8) mol/ L) or Hexamethonium (10(-5) mol/ L) or Indomethacin (5 x 10(-7) mol/ L) was given 2 minutes before the administration of Dangshen, it did not abolish its dose related manner. Atropine apparently reduced the increasing action of 10% and 30% Dangshen on the resting tesion of LM of fundus (P<0.05), 30%, 100% and 200% Dangshen on bodied strips (P<0.05), 100% and 200% Dangshen on antral strips (P<0.05). Hexamethonium reduced the increasing action of 10% and 30% Dangshen on the resting tesion of LM of fundus (P<0.05 and P<0.05), 30%, 100% and 200% Dangshen on bodied strips (P<0.05), and 100% and 200% Dangshen on pyloric strips (P<0.05). Indomethacin inhibited the effect of 10% Dangshen on the resting tesion of LM of fundus (P<0.05), but did not affect the exciting action of Dangshen on strips of body, antrum and pylorus. CONCLUSION The results showed that Dangshen possessed exciting action on the isolated gastric smooth muscle strips of the rat. The exciting action of Dangshen was partially mediated via cholinergic M and N receptors.
学科主题	Gastroenterology & Hepatology
出版地	BEIJING
语种	英语
WOS记录号	WOS:000076327100022
内容类型	期刊论文
源URL	[http://ir.lzu.edu.cn/handle/262010/121308]
专题	基础医学院_期刊论文
通讯作者	Zheng, TZ (reprint author), Lanzhou Med Coll, Dept Physiol, Lanzhou 730000, Gansu Province, Peoples R China.
推荐引用方式 GB/T 7714	Zheng, TZ,Li, W,Qu, SY,et al. Effects of Dangshen on isolated gastric muscle strips in rats[J]. WORLD JOURNAL OF GASTROENTEROLOGY,1998,4(4):354-356.
APA	Zheng, TZ.,Li, W.,Qu, SY.,Ma, YM.,Ding, YH.,...&Zheng, TZ .(1998).Effects of Dangshen on isolated gastric muscle strips in rats.WORLD JOURNAL OF GASTROENTEROLOGY,4(4),354-356.
MLA	Zheng, TZ,et al."Effects of Dangshen on isolated gastric muscle strips in rats".WORLD JOURNAL OF GASTROENTEROLOGY 4.4(1998):354-356.