Regulatory effects of dietary L-Arg supplementation on the innate immunity and antioxidant ability in broiler chickens

doi:10.1016/S2095-3119(16)61404-1

CORC > 中国农业科学院 > 北京畜牧兽医研究所

	Regulatory effects of dietary L-Arg supplementation on the innate immunity and antioxidant ability in broiler chickens
	Hu Yadi; Tan Jianzhuang; Qi Ji; Zhang Hongfu
刊名	Journal of Integrative Agriculture
	2016
卷号	15 期号:11 页码:2578-2587
关键词	arginine innate immunity antioxidant ability broiler
ISSN号	2095-3119
DOI	10.1016/S2095-3119(16)61404-1
英文摘要	Here, we investigated the effect of dietary arginine (Arg) supplementation on innate immunity and the antioxidant ability of broiler chickens. The experiment was designed as a single-factorial arrangement (n=8 cages/treatment, six birds/cage), and we used four dietary Arg concentrations (10.0, 15.0, 20.0 or 25.0 g kg~(–1)). On day 21, the birds were killed to obtain spleen, cecal tonsil and liver samples to determine the gene expression and antioxidant characteristics. Increasing the Arg concentration linearly decreased (P<0.05) the mRNA expression of splenic interleukin-18 (IL-18) and tumor necrosis factor-α (TNF-α). Dietary Arg supplementation quadratically decreased (P<0.05) the expression of interleukin-1b (IL-1b) and interferon-γ (IFN-γ) mRNA in the spleen. Increasing Arg concentrations linearly and quadratically reduced the expression of IL-18 mRNA in the spleen. Meanwhile, increasing dietary Arg supplementation linearly and quadratically increased the lymphotactin mRNA (P<0.05) expression, and linearly increased the macrophage inflammatory protein-1β (MIP-1β) and toll-like receptor 15 (TLR15) mRNA expression in the cecal tonsils. Dietary Arg supplementation linearly (P<0.05) increased the glutathione peroxidase (GSH-Px), catalase (CAT), and lysozyme (LZM) activities in the liver. However, the malondialdehyde (MDA) activity in the liver was not influenced by the dietary Arg concentration (P>0.05). No significant (P>0.05) effect was found on the activity of superoxide dismutase (SOD) in the liver. Thus high levels of Arg supplementation (>20.0 g kg~(–1)) may potentially suppress the innate immunity of broiler chickens, and dietary Arg supplementation enhances the antioxidant activity in broiler chickens.
学科主题	畜牧、动物医学、狩猎、蚕、蜂
语种	中文
内容类型	期刊论文
源URL	[http://ir.nais.net.cn/handle/2HMLN22E/119676]
专题	北京畜牧兽医研究所
作者单位	Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, State Key Laboratory of Animal Nutrition, Beijing, 100081
推荐引用方式 GB/T 7714	Hu Yadi,Tan Jianzhuang,Qi Ji,et al. Regulatory effects of dietary L-Arg supplementation on the innate immunity and antioxidant ability in broiler chickens[J]. Journal of Integrative Agriculture,2016,15(11):2578-2587.
APA	Hu Yadi,Tan Jianzhuang,Qi Ji,&Zhang Hongfu.(2016).Regulatory effects of dietary L-Arg supplementation on the innate immunity and antioxidant ability in broiler chickens.Journal of Integrative Agriculture,15(11),2578-2587.
MLA	Hu Yadi,et al."Regulatory effects of dietary L-Arg supplementation on the innate immunity and antioxidant ability in broiler chickens".Journal of Integrative Agriculture 15.11(2016):2578-2587.