Regulatory effects of dietary L-Arg supplementation on the innate immunity and antioxidant ability in broiler chickens | |
Hu Yadi; Tan Jianzhuang; Qi Ji; Zhang Hongfu | |
刊名 | Journal of Integrative Agriculture
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2016 | |
卷号 | 15期号:11页码:2578-2587 |
关键词 | arginine innate immunity antioxidant ability broiler |
ISSN号 | 2095-3119 |
DOI | 10.1016/S2095-3119(16)61404-1 |
英文摘要 | Here, we investigated the effect of dietary arginine (Arg) supplementation on innate immunity and the antioxidant ability of broiler chickens. The experiment was designed as a single-factorial arrangement (n=8 cages/treatment, six birds/cage), and we used four dietary Arg concentrations (10.0, 15.0, 20.0 or 25.0 g kg~(–1)). On day 21, the birds were killed to obtain spleen, cecal tonsil and liver samples to determine the gene expression and antioxidant characteristics. Increasing the Arg concentration linearly decreased (P<0.05) the mRNA expression of splenic interleukin-18 (IL-18) and tumor necrosis factor-α (TNF-α). Dietary Arg supplementation quadratically decreased (P<0.05) the expression of interleukin-1b (IL-1b) and interferon-γ (IFN-γ) mRNA in the spleen. Increasing Arg concentrations linearly and quadratically reduced the expression of IL-18 mRNA in the spleen. Meanwhile, increasing dietary Arg supplementation linearly and quadratically increased the lymphotactin mRNA (P<0.05) expression, and linearly increased the macrophage inflammatory protein-1β (MIP-1β) and toll-like receptor 15 (TLR15) mRNA expression in the cecal tonsils. Dietary Arg supplementation linearly (P<0.05) increased the glutathione peroxidase (GSH-Px), catalase (CAT), and lysozyme (LZM) activities in the liver. However, the malondialdehyde (MDA) activity in the liver was not influenced by the dietary Arg concentration (P>0.05). No significant (P>0.05) effect was found on the activity of superoxide dismutase (SOD) in the liver. Thus high levels of Arg supplementation (>20.0 g kg~(–1)) may potentially suppress the innate immunity of broiler chickens, and dietary Arg supplementation enhances the antioxidant activity in broiler chickens. |
学科主题 | 畜牧、动物医学、狩猎、蚕、蜂 |
语种 | 中文 |
内容类型 | 期刊论文 |
源URL | [http://ir.nais.net.cn/handle/2HMLN22E/119676] ![]() |
专题 | 北京畜牧兽医研究所 |
作者单位 | Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, State Key Laboratory of Animal Nutrition, Beijing, 100081 |
推荐引用方式 GB/T 7714 | Hu Yadi,Tan Jianzhuang,Qi Ji,et al. Regulatory effects of dietary L-Arg supplementation on the innate immunity and antioxidant ability in broiler chickens[J]. Journal of Integrative Agriculture,2016,15(11):2578-2587. |
APA | Hu Yadi,Tan Jianzhuang,Qi Ji,&Zhang Hongfu.(2016).Regulatory effects of dietary L-Arg supplementation on the innate immunity and antioxidant ability in broiler chickens.Journal of Integrative Agriculture,15(11),2578-2587. |
MLA | Hu Yadi,et al."Regulatory effects of dietary L-Arg supplementation on the innate immunity and antioxidant ability in broiler chickens".Journal of Integrative Agriculture 15.11(2016):2578-2587. |
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