Quantitative trait loci for the number of vertebrae on Sus scrofa chromosomes 1 and 7 independently influence the numbers of thoracic and lumbar vertebrae in pigs

doi:10.1016/S2095-3119(15)61084-X

CORC > 中国农业科学院 > 北京畜牧兽医研究所

	Quantitative trait loci for the number of vertebrae on Sus scrofa chromosomes 1 and 7 independently influence the numbers of thoracic and lumbar vertebrae in pigs
	Zhang Longchao; Liu Xin; Liang Jing; Yan Hua; Zhao Kebin; Li Na; Pu Lei; Shi Huibi; Zhang Yuebo; Wang Ligang
刊名	Journal of Integrative Agriculture
	2015
卷号	14 期号:10 页码:2027-2033
关键词	candidate gene genetic variant genome-wide association study number of vertebrae pig QTLs
ISSN号	2095-3119
DOI	10.1016/S2095-3119(15)61084-X
英文摘要	Although quantitative trait loci (QTLs) for number of thoracic-lumbar vertebrae have been identified on Sus scrofa chromosomes (SSCs) 1 and 7, the influence of these QTLs on the thoracic and lumbar vertebrae is not clear. The aim of this study was to identify single nucleotide polymorphisms (SNPs) associated with total number of thoracic-lumbar vertebrae and for each trait (number of thoracic and lumbar vertebrae) separately. A total of 581 individuals from an F_2 Large White譓inzhu population were genotyped using an SNP60K chip. Performing a genome-wide association study (GWAS) for total number of thoracic-lumbar vertebrae, 38 significant SNPs were identified in two QTL regions located on SSC1 and SSC7. Performing a GWAS for number of thoracic vertebrae only, 72 significant SNPs were located on SSC7. While performing a GWAS for number of lumbar vertebrae only, 17 significant SNPs were identified on SSC1. Gene mining suggested that the gene encoding orphan nuclear receptor, germ cell nuclear factor (NR6A1) on SSC1 was a strong candidate affecting the number of lumbar vertebrae in pigs. Additionally, genes encoding vertnin (VRTN), prospero homeobox 2 (PROX2), Finkel-Biskis-Jinkins murine osteosarcoma viral oncogene homolog (FOS), and transforming growth factor beta 3 (TGFB3) may be important candidates affecting the number of thoracic vertebrae in pigs. QTLs on SSC1 and SSC7 independently influenced the numbers of thoracic and lumbar vertebrae. These results shed light on the complex genetic background of vertebrae development in pigs.
学科主题	畜牧、动物医学、狩猎、蚕、蜂
语种	中文
内容类型	期刊论文
源URL	[http://ir.nais.net.cn/handle/2HMLN22E/119669]
专题	北京畜牧兽医研究所
作者单位	Institute of Animal Sciences,Chinese Academy of Agricultural Sciences, Key Laboratory of Farm Animal Genetic Resources and Germplasm Innovation, Ministry of Agriculture, Beijing, 100193
推荐引用方式 GB/T 7714	Zhang Longchao,Liu Xin,Liang Jing,et al. Quantitative trait loci for the number of vertebrae on Sus scrofa chromosomes 1 and 7 independently influence the numbers of thoracic and lumbar vertebrae in pigs[J]. Journal of Integrative Agriculture,2015,14(10):2027-2033.
APA	Zhang Longchao.,Liu Xin.,Liang Jing.,Yan Hua.,Zhao Kebin.,...&Wang Lixian.(2015).Quantitative trait loci for the number of vertebrae on Sus scrofa chromosomes 1 and 7 independently influence the numbers of thoracic and lumbar vertebrae in pigs.Journal of Integrative Agriculture,14(10),2027-2033.
MLA	Zhang Longchao,et al."Quantitative trait loci for the number of vertebrae on Sus scrofa chromosomes 1 and 7 independently influence the numbers of thoracic and lumbar vertebrae in pigs".Journal of Integrative Agriculture 14.10(2015):2027-2033.